The Registry of Toxic Effects of Chemical Substances

8 - Quinolinol, copper (II) chelate

RTECS #: VC5250000

CAS #: 10380-28-6

UPDATE: August 2003 MW: 351.86 MF: C18H12CuN2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bioquin 1
  2. Copper - 8
  3. Copper, bis (8 - quinolinolato - N (sup 1) ,O (sup 8) ) -
  4. Copper 8 - hydroxyquinolate
  5. Copper hydroxyquinolinate
  6. Copper 8 - hydroxyquinolinate
  7. Copper 8 - hydroxyquinoline
  8. Copper oxinate
  9. Copper (2+) oxinate
  10. Copper oxine
  11. Copper oxyquinolate
  12. Copper oxyquinoline
  13. Copper quinolate
  14. Copper 8 - quinolate
  15. Copper 8 - quinolinol
  16. Copper quinolinolate
  17. Copper 8 - quinolinolate
  18. Cunilate
  1. Cunilate 2472
  2. Cupric 8 - hydroxyquinolate
  3. Cupric 8 - quinolinolate
  4. Dokirin
  5. Fruitdo
  6. 8 - Hydroxyquinoline copper complex
  7. Milmer
  8. Oxime copper
  9. Oxine copper
  10. Oxine cuivre
  11. Oxyquinolinoleate de cuivre (French)
  12. Bis (8 - oxyquinoline) copper
  13. Bis (8 - quinolinato) copper
  14. Bis (quinolin - 8 - olato) copper (IUPAC)
  15. Bis (8 - quinolinolato) copper
  16. Cellu - quin
  17. Quinondo


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) MUREAV 116,185,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 156 mg/kg/39 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 24,109,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 820 mg/m3 N/R NNGADV 16,563,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 67 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		TXAPA9 5,599,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 22 mg/kg N/R NNGADV 16,563,1991
oral
mouse 		lethal dose (50 percent kill): 3,940 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		GISAAA 51(1),85,1986
oral
rat 		lethal dose (50 percent kill): 9,930 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		GISAAA 51(1),85,1986
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R NNGADV 16,563,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 54,600 mg/kg/2 year- continuous Gastrointestinal: Malabsorption

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Change in gall bladder structure or function 		NNGADV 16,563,1991
oral
mouse 		lowest published toxic dose: 21,840 mg/kg/13 week- continuous Liver: Other changes

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		NNGADV 16,563,1991
oral
rat 		lowest published toxic dose: 48 gm/kg/30 day- intermittent Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 51(1),86,1986
oral
rat 		lowest published toxic dose: 87,600 mg/kg/2 year- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight 		NNGADV 16,563,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,103,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 15,103,1977
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,303,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82785;
Number of Industries 3;
Total Number of Facilities 28;
Number of Occupations 7;
Total Number of Employees Exposed 792
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82785;
Number of Industries 3;
Total Number of Facilities 33;
Number of Occupations 3;
Total Number of Employees Exposed 406


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as fungicide to prevent mold growth, control fungus disease in agriculture
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as fungicide to prevent mold growth, control fungus disease in agriculture

NIOSH PROFILE (COPPER and COMPOUNDS), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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