The Registry of Toxic Effects of Chemical Substances

Quinoline

RTECS #: VA9275000

CAS #: 91-22-5

UPDATE: November 2004 MW: 129.17 MF: C9H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Azanaphthalene
  2. B - 500
  3. 1 - Benzazine
  4. Benzo (b) pyridine
  5. Chinoleine
  1. Chinolin (Czech)
  2. Chinoline
  3. Leucol
  4. Leukol
  5. USAF EK - 218


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,848,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 500 µg/L ENMUDM 7,1,1985
cytogenetic analysis hamster lung 100 mg/L ATSUDG 4,41,1980
cytogenetic analysis non-mammalian species embryo 460 mmol/L/10 minute- continuous CHROAU 56,289,1976
DNA adduct Escherichia coli 30 µmol/L MUREAV 89,95,1981
DNA damage rat liver 1 mmol/L SinJF# 26OCT1982
unscheduled DNA synthesis rat liver 100 µmol/L MUREAV 221,263,1989
mutation in microorganisms hamster ovary 80 µmol/L (+enzymatic activation step) ENMUDM 4,395,1982
mutation in microorganisms Salmonella typhimurium 25 µg/plate (-enzymatic activation step) MUREAV 174,247,1986
micronucleus test intraperitoneal
mouse 		50 mg/kg TCMUD8 9,111,1989
mutation in mammalian somatic cells mouse lymphocyte 700 mg/L EMMUEG 12,85,1988
mutation in mammalian somatic cells intraperitoneal
mouse 		200 mg/kg/4 day- continuous MUREAV 412,161,1998
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems non-mammalian species embryo 460 mmol/L/10 minute- continuous CHROAU 56,289,1976
other mutation test systems rat liver 500 µmol/L CBINA8 29,257,1980
sister chromatid exchange hamster ovary 110 µg/L ENMUDM 7,1,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 9,042 µg/kg/15 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		JJCREP 78,139,1987
oral
mouse 		lowest published toxic dose: 50 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		GANNA2 68,785,1977
oral
rat 		lowest published toxic dose: 7,770 mg/kg/37 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CNREA8 36,329,1976
oral
rat 		toxic dose : 23 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		GANNA2 68,785,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 331 mg/kg N/R 85JCAE -,848,1986
subcutaneous
frog 		lowest published lethal dose: 150 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
skin
rabbit 		lethal dose (50 percent kill): 540 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84566;
Number of Industries 7;
Total Number of Facilities 258;
Number of Occupations 7;
Total Number of Employees Exposed 29,238
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84566;
Number of Industries 9;
Total Number of Facilities 456;
Number of Occupations 16;
Total Number of Employees Exposed 4,241;
Total Number of Female Employees Exposed 810


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antimalarial agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as an antimalarial agent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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