The Registry of Toxic Effects of Chemical Substances

2 - Pyrrolidinone, 1 - vinyl -

RTECS #: UY6107000

CAS #: 88-12-0

UPDATE: May 2004 MW: 111.16 MF: C6H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Ethenyl - 2 - pyrrolidinone (9CI)
  2. Vinylbutyrolactam
  3. N - Vinylpyrrolidinone
  4. 1 - Vinyl - 2 - pyrrolidinone
  5. N - Vinyl - 2 - pyrrolidinone
  1. Vinylpyrrolidone
  2. N - Vinylpyrrolidone
  3. N - Vinyl - 2 - pyrrolidone
  4. 1 - Vinyl - 2 - pyrrolidone
  5. V - Pyrol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BurLW# 02NOV1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Liver: Tumors 		FCTOD7 35,1041,1997


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 3,200 mg/m3/4 hour N/R BurLW# 02NOV1978
oral
rat 		lethal dose (50 percent kill): 1,470 mg/kg N/R BurLW# 02NOV1978
skin
rabbit 		lethal dose (50 percent kill): 560 mg/kg N/R BurLW# 02NOV1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 45 ppm/6 hour/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 35,1061,1997
inhalation
mouse 		lowest published toxic concentration: 45 ppm/6 hour/1 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 35,1061,1997
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/7 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		FCTOD7 35,1061,1997
inhalation
rat 		lowest published toxic concentration: 45 ppm/6 hour/1 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 35,1061,1997
inhalation
rat 		lowest published toxic concentration: 15 ppm/6 hour/7 week- intermittent Olfaction: Other olfaction effects FCTOD7 35,1061,1997
inhalation
rat 		lowest published toxic concentration: 120 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FCTOD7 35,1061,1997
inhalation
rat 		lowest published toxic concentration: 20 ppm/6 hour/1 year- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 35,1061,1997
oral
rat 		lowest published toxic dose: 2,600 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight 		FCTOD7 35,1061,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,461,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1181,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,461,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1181,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84629;
Number of Industries 1;
Total Number of Facilities 1,085;
Number of Occupations 1;
Total Number of Employees Exposed 4,340
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84629;
Number of Industries 6;
Total Number of Facilities 201;
Number of Occupations 11;
Total Number of Employees Exposed 6,772;
Total Number of Female Employees Exposed 1,243


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of POLYVINYL PYRROLIDONE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BurLW# Personal Communication from L.W. Burnette, Material Safety Dept., GAF Corp., 1361 Alps Rd., Wayne, NJ 07470, Nov. 2, 1978
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-

Used in the manufacture of POLYVINYL PYRROLIDONE

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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