The Registry of Toxic Effects of Chemical Substances

2 - Pyrrolidinone, 1 - methyl -

RTECS #: UY5790000

CAS #: 872-50-4

UPDATE: November 2004 MW: 99.15 MF: C5H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. N - Methylpyrrolidinone
  2. N - Methyl - 2 - pyrrolidinone
  3. 1 - Methyl - 2 - pyrrolidinone
  4. 1 - Methyl - 5 - pyrrolidinone
  5. N - Methylpyrrolidone
  1. N - Methyl - alpha - pyrrolidone
  2. N - Methyl - 2 - pyrrolidone
  3. 1 - Methyl - 2 - pyrrolidone
  4. M - Pyrol
  5. NMP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate FCTOD7 26,475,1988


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 154 mmol/L EMMUEG 11,31,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 150 ppm/6 hour (7-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		NETEEC 16,241,1994
inhalation
rat 		lowest published toxic dose: 116 ppm/6 hour (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) DCTODJ 18,271,1995
intraperitoneal
mouse 		lowest published toxic dose: 7,625 mg/kg (11-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		EPASR* 8EHQ-1087-0695
intraperitoneal
rat 		lowest published toxic dose: 166 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BIRUAA 14,38,1976
oral
mouse 		lowest published toxic dose: 12,825 mg/kg (11-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		EPASR* 8EHQ-1087-0695
oral
rat 		lowest published toxic dose: 9,700 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		EPASR* 8EHQ-1087-0695
oral
rat 		lowest published toxic dose: 7.5 gm/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTOD7 40,1705,2002
oral
rat 		lowest published toxic dose: 11.25 gm/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) FCTOD7 40,1705,2002
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTOD7 40,1705,2002
oral
rat 		lowest published toxic dose: 3,750 mg/kg (6-20 day pregnant) Reproductive: Other developmental abnormalities FCTOD7 40,1705,2002
skin
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 2,73,1982
skin
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 2,73,1982
skin
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** OTS0555033


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 784 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** OTS0559204-1


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 1 gm/m3 N/R NTIS** OTS0534725
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,050 mg/kg N/R EPASR* 8EHQ-1087-0695
intraperitoneal
rat 		lethal dose (50 percent kill): 2,472 mg/kg N/R ARZNAD 26,1581,1976
intravenous
dog 		lethal dose (50 percent kill): 63,300 µg/kg N/R IYKEDH 18,922,1987
intravenous
mouse 		lethal dose (50 percent kill): 54,500 µg/kg N/R IYKEDH 18,922,1987
intravenous
rat 		lethal dose (50 percent kill): 80,500 µg/kg N/R IYKEDH 18,922,1987
oral
mouse 		lethal dose (50 percent kill): 5,130 mg/kg N/R EPASR* 8EHQ-1087-0695
oral
rat 		lethal dose (50 percent kill): 3,914 mg/kg N/R ARZNAD 26,1581,1976
oral
rat 		lowest published toxic dose: 750 mg/kg Behavioral: Food intake (animal) FCTOD7 40,1705,2002
subcutaneous
rat 		lethal dose (50 percent kill): >2 gm/kg N/R USXXAM #4882359
skin
human 		lowest published toxic dose: 5 pph/15 minute Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 134,265,2002
skin
rabbit 		lethal dose (50 percent kill): 8 gm/kg N/R NPIRI* 1,84,1974
unreported route
rat 		lethal dose (50 percent kill): 7 gm/kg N/R 34ZIAG -,408,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 400 mg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 9,222,1987
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition FAATDF 9,222,1987
inhalation
rat 		lowest published toxic concentration: 423 mg/m3/6 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0534849
inhalation
rat 		lowest published toxic concentration: 800 ppm/6 hour/6 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition NTIS** OTS0532511
inhalation
rat 		lowest published toxic concentration: 60 ppm/6 hour/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,583,2003
inhalation
rat 		lowest published toxic concentration: 120 ppm/6 hour/16 day- intermittent Behavioral: Food intake (animal) FCTOD7 41,583,2003
intramuscular
rat 		lowest published toxic dose: 7,500 mg/kg/15 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 40,1705,2002
oral
mouse 		lowest published toxic dose: 33,600 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 15,83,1995
oral
mouse 		lowest published toxic dose: 10,800 mg/kg/90 day- continuous Endocrine: Changes in spleen weight NTIS** OTS0528073
oral
rat 		lowest published toxic dose: 655 gm/kg/2 year- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 48,344,1999
oral
rat 		lowest published toxic dose: 30,240 mg/kg/28 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 15,83,1995
oral
rat 		lowest published toxic dose: 33,750 mg/kg/90 day- intermittent Behavioral: Muscle weakness TOXID9 30,301,1996
oral
rat 		lowest published toxic dose: 2 gm/kg/4 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 40,1705,2002
skin
rabbit 		lowest published toxic dose: 32 mL/kg/20 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0528073


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm, JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (200 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 50 ppm (200 mg/m3), KTV 75 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (103 mg/m3), short term exposure limit 75 ppm, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 80 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1569;
Number of Industries 30;
Total Number of Facilities 2,458;
Number of Occupations 43;
Total Number of Employees Exposed 25,255
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1569;
Number of Industries 63;
Total Number of Facilities 3,902;
Number of Occupations 73;
Total Number of Employees Exposed 85,169;
Total Number of Female Employees Exposed 23,478


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIRUAA Biologische Rundschau. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1963-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as a solvent and emulsifier

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 26138-58-9
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