The Registry of Toxic Effects of Chemical Substances

2 - Pyrrolidinone

RTECS #: UY5715000

CAS #: 616-45-5

UPDATE: September 2000 MW: 85.12 MF: C4H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. gamma - Aminobutyric acid lactam
  2. 4 - Aminobutyric acid lactam
  3. gamma - Aminobutyric lactam
  4. gamma - Aminobutyrolactam
  5. 2 - Oxopyrrolidine
  6. 2 - Pyrol
  7. alpha - Pyrrolidinone
  8. Butyrolactam
  1. gamma - Butyrolactam
  2. 2 - Ketopyrrolidine
  3. LAM
  4. Pyrrolidon (German)
  5. Pyrrolidone
  6. alpha - Pyrrolidone
  7. 2 - Pyrrolidone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 352,200 µmol/L EMMUEG 11,31,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 19 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system 		NTIS** OTS0521310-2


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,700 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		AITEAT 13,70,1965
intraperitoneal
rat 		lethal dose (50 percent kill): 160 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		TVLMB8 31,160,1979
intravenous
rat 		lethal dose (50 percent kill): >7,200 mg/kg N/R USXXAM #3380887
intravenous
rabbit 		lowest published lethal dose: 800 mg/kg N/R AITEAT 13,70,1965
oral
guinea pig 		lethal dose (50 percent kill): 6,500 mg/kg N/R 34ZIAG -,508,1969
oral
rat 		lethal dose (50 percent kill): 328 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		TVLMB8 31,160,1979
subcutaneous
mouse 		lowest published lethal dose: 10 gm/kg N/R AEXPBL 50,199,1903


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6,480 µL/kg/90 day- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0521310-3


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1513;
Number of Industries 7;
Total Number of Facilities 465;
Number of Occupations 15;
Total Number of Employees Exposed 2,456
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1513;
Number of Industries 2;
Total Number of Facilities 35;
Number of Occupations 3;
Total Number of Employees Exposed 1,215;
Total Number of Female Employees Exposed 260


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, solvent and emulsifier
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TVLMB8 Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta. Transactions of the Volgograd State Medical Institute. (Volgogradskii Gosudarstvennyi Meditskinskii Institut, Volgograd, USSR) 1961-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as a chemical intermediate, solvent and emulsifier

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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