The Registry of Toxic Effects of Chemical Substances

Pyridine, 2 - amino -

RTECS #: US1575000

CAS #: 504-29-0

UPDATE: November 2004 MW: 94.13 MF: C5H6N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. alpha - Aminopyridine
  2. Amino - 2 pyridine
  3. 2 - Aminopyridine
  4. 2 - Aminopyridine (ACGIH:OSHA)
  1. alpha - Pyridinamine
  2. alpha - Pyridylamine
  3. 2 - Pyridylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 4 mg/kg Behavioral: Convulsions or effect on seizure threshold AJEBAK 36,365,1958
inhalation
human 		lowest published toxic concentration: 5 ppm/5 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Antipsychotic 		IMSUAI 19,317,1950
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R USXXAM #3816470
intraperitoneal
rat 		lethal dose (50 percent kill): 48 mg/kg N/R GISAAA 57(9-10),64,1992
intravenous
mouse 		lethal dose (50 percent kill): 23 mg/kg Behavioral: Convulsions or effect on seizure threshold APFRAD 26,345,1968
intravenous
rat 		lethal dose (50 percent kill): 29 mg/kg N/R AEPPAE 211,367,1950
oral
wild bird 		lethal dose (50 percent kill): 31,600 µg/kg N/R AECTCV 12,355,1983
oral
mouse 		lethal dose (50 percent kill): 145 mg/kg N/R GISAAA 57(9-10),64,1992
oral
quail 		lethal dose (50 percent kill): 133 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 200 mg/kg N/R 85JCAE -,838,1986
subcutaneous
mouse 		lethal dose (50 percent kill): 70 mg/kg N/R AEPPAE 226,163,1955
skin
guinea pig 		lethal dose (50 percent kill): 500 mg/kg N/R 85JCAE -,838,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (2 mg/m3) DTLVS* 3,11,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (2 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (2 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (2 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (2 mg/m3), short term exposure limit 1.5 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (2 mg/m3), short term exposure limit 2 ppm (7.8 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-AMINOPYRIDINE-air 10 hour time-weighted average 0.5 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 05215;
Number of Industries 3;
Total Number of Facilities 61;
Number of Occupations 4;
Total Number of Employees Exposed 3,159;
Total Number of Female Employees Exposed 429


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86.
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

RTECS Compound Description:
   Human Data

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