The Registry of Toxic Effects of Chemical Substances
1H - Pyrazole - 3 - carbonitrile, 5 - amino - 1 - (2,6 - dichloro - 4 - (trifluoromethyl) phenyl) - 4 - ( (trifluoromethyl) sulfinyl) - RTECS #: UQ4430250
CAS #: 120068-37-3
The Registry of Toxic Effects of Chemical Substances
1H - Pyrazole - 3 - carbonitrile, 5 - amino - 1 - (2,6 - dichloro - 4 - (trifluoromethyl) phenyl) - 4 - ( (trifluoromethyl) sulfinyl) - |
| UPDATE: November 2003 | MW: 437.16 | MF: C12H4Cl2F6N4OS |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mammal (species unspecified)
lowest published toxic dose: 390 mg/kg (6-22 day pregnant/10 day after birth)
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Reproductive: Effects on newborn: Behavioral
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FEREAC 63,38486,1998
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mammal (species unspecified)
lethal dose (50 percent kill): 92 mg/kg
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N/R
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FEREAC 63,38488,1998
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | dog
lowest published toxic dose: 910 mg/kg/13 week- intermittent
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555596
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oral | mouse
lowest published toxic dose: 554 mg/kg/6 week- continuous
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Behavioral: Irritability | Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555580
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oral | rat
lowest published toxic dose: 420 mg/kg/2 week- continuous
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Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571733
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oral | rat
lowest published toxic dose: 336 mg/kg/4 week- continuous
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Liver: Other changes | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0571374
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oral | rat
lowest published toxic dose: 1,638 mg/kg/13 week- continuous
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Liver: Other changes | Liver: Changes in liver weight Endocrine: Changes in thyroid weight
NTIS** OTS0571976
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oral | rat
lowest published toxic dose: 10,950 mg/kg/1 year- continuous
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Kidney, Ureter, and Bladder: Other changes | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0537614
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Active registration
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RBREV* -,370,1998
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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