The Registry of Toxic Effects of Chemical Substances

n - Propyl nitrate

RTECS #: UK0350000

CAS #: 627-13-4

UPDATE: November 2004 MW: 105.11 MF: C3H7NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Nitrate de propyle normal (French)
  2. Nitric acid, propyl ester
  3. Propyl nitrate
  1. Propylester kyseliny dusicne (Czech)
  2. n - Propyl nitrate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 5,816 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		AIHAAP 19,80,1958
inhalation
rat 		lowest published lethal concentration: 5,816 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		AIHAAP 19,80,1958
intravenous
cat 		lowest published lethal dose: 100 mg/kg N/R JPETAB 118,77,1956
intravenous
dog 		lowest published lethal dose: 200 mg/kg N/R JPETAB 118,77,1956
intravenous
rabbit 		lethal dose (50 percent kill): 200 mg/kg N/R JPETAB 118,77,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm;short term exposure limit 40 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 40 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (110 mg/m3) DTLVS* 3,217,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (110 mg/m3), short term exposure limit 40 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (107 mg/m3), short term exposure limit 40 ppm (172 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (105 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 25 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (110 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 10 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (110 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (110 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 40 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 40 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-PROPYL NITRATE-air 10 hour time-weighted average 25 ppm;
short term exposure limit 40 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7139;
Number of Industries 2;
Total Number of Facilities 30;
Number of Occupations 2;
Total Number of Employees Exposed 1,844;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a fuel ignition promoter, in rocket fuels, and as an intermediate

Click Here for Additional Information about RTECS