The Registry of Toxic Effects of Chemical Substances

2 - Propyn - 1 - ol

RTECS #: UK5075000

CAS #: 107-19-7

UPDATE: November 2004 MW: 56.07 MF: C3H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Propyne - 3 - ol
  2. 2 - Propynyl alcohol
  3. Acetylene carbinol
  4. Agrisynth PA
  5. Ethynylcarbinol
  1. Methanol, ethynyl -
  2. Propargyl alcohol
  3. Propargyl alcohol (ACGIH:OSHA)
  4. RCRA waste number P102


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 400 µmol/L MUREAV 320,273,1994
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (+enzymatic activation step) UNMI** DA85-04850


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 3 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse 		lethal concentration (50 percent kill): 2,000 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 8,97,1966
inhalation
mouse 		lethal concentration (50 percent kill): 1,750 mg/m3 Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,122,1984
inhalation
rat 		lethal concentration (50 percent kill): 873 ppm/2 hour N/R GAFCC*
inhalation
rat 		lethal concentration (50 percent kill): 1,800 mg/m3 Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,122,1984
oral
guinea pig 		lethal dose (50 percent kill): 60 mg/kg N/R DTLVS* 4,346,1980
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 50 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage 		TPKVAL 8,97,1966
oral
mouse 		lethal dose (50 percent kill): 50 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,122,1984
oral
rat 		lethal dose (50 percent kill): 20 mg/kg N/R 38MKAJ 2C,4672,1982
oral
rat 		lethal dose (50 percent kill): 55 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,122,1984
subcutaneous
rabbit 		lowest published lethal dose: 25 mg/kg N/R BDBU** -,-,1930
skin
rabbit 		lethal dose (50 percent kill): 16 mg/kg Skin: After systemic exposure: Dermatitis, other 38MKAJ 2C,4672,1982
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 53 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 100 mg/m3/4 hour/60 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,122,1994
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 5 mg/m3/4 hour/28 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,122,1994
inhalation
mouse 		lowest published toxic concentration: 230 mg/m3/2 hour/3 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 8,97,1966
inhalation
mouse 		lowest published toxic concentration: 25,300 ppb/6 hour/14 day- intermittent Olfaction: Other olfaction effects JJATDK 15,207,1995
inhalation
rat 		lowest published toxic concentration: 230 mg/m3/2 hour/3 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 8,97,1966
inhalation
rat 		lowest published toxic concentration: 7 mg/m3/4 hour/22 week- intermittent Vascular: BP lowering not characterized in autonomic section

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		TPKVAL 8,97,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (2 mg/m3) (skin) DTLVS* 3,215,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (2.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (2.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (2 mg/m3), short term exposure limit 3 ppm (6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 2 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (2.3 mg/m3), short term exposure limit 3 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPARGYL ALCOHOL-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 62000;
Number of Industries 7;
Total Number of Facilities 471;
Number of Occupations 11;
Total Number of Employees Exposed 30,791
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 62000;
Number of Industries 56;
Total Number of Facilities 3,447;
Number of Occupations 38;
Total Number of Employees Exposed 54,359;
Total Number of Female Employees Exposed 19,934


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as corrosion inhibitor, solvent stabilizer, soil fumigant, and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
OSHA ANALYTICAL METHOD #97


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BDBU** "Zur Pharmakologie Ungesattigter Alkohole, Dissertation," Bock, H., Pharmakologischen Institut der Universitat Breslau, Poland, 1930
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UNMI** University Microfilms International. (300 N. Zeeb Rd., Ann Arbor, MI 48106)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as corrosion inhibitor, solvent stabilizer, soil fumigant, and chemical intermediate

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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