The Registry of Toxic Effects of Chemical Substances

Propyne

RTECS #: UK4250000

CAS #: 74-99-7

UPDATE: November 2004 MW: 40.07 MF: C3H4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Propyne (9CI)
  2. Acetylene, methyl -
  3. Allylene
  4. Methyl acetylene
  1. Methyl acetylene (ACGIH:OSHA)
  2. Propine
  3. Propyne (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 10 pph (-enzymatic activation step) MUREAV 307,335,1994
mutation in microorganisms Escherichia coli 25 pph (-enzymatic activation step) MUREAV 307,335,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 47,000 mg/m3/7 minute Behavioral: Excitement

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		VCVGH* -,73,1990
inhalation
rat 		lethal concentration : >42,000 ppm/6 hour Behavioral: General anesthetic

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia 		AMIHAB 15,20,1957
inhalation
rat 		lowest published toxic concentration: 47,000 mg/m3/7 minute Behavioral: Excitement

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		VCVGH* -,73,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 28,700 ppm/6 hour/26 week- intermittent Eye: Mydriasis (pupilliary dilation)

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHAB 15,20,1957
inhalation
rat 		lowest published toxic concentration: 28,700 ppm/6 hour/26 week- intermittent Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 15,20,1957


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (1650 mg/m3) DTLVS* 3,153,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (1650 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (1650 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (1650 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (1650 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (1650 mg/m3), short term exposure limit 1250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (1650 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (1640 mg/m3), short term exposure limit 1250 ppm (2050 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1000 ppm (1650 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (1650 mg/m3), short term exposure limit 1250 ppm (2065 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (1650 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (1650 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1650 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (1650 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (1650 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (1650 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1000 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACETYLENE-air 10 hour time-weighted average 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46435;
Number of Industries 9;
Total Number of Facilities 311;
Number of Occupations 13;
Total Number of Employees Exposed 5,033
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46435;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 7;
Total Number of Employees Exposed 119;
Total Number of Female Employees Exposed 6


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Mutagen

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