The Registry of Toxic Effects of Chemical Substances

Propylamine

RTECS #: UH9100000

CAS #: 107-10-8

UPDATE: September 2000 MW: 59.13 MF: C3H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Aminopropane
  2. Monopropylamine
  3. Mono - n - propylamine
  4. Propanamine
  1. 1 - Propanamine
  2. n - Propylamine
  3. 1 - Propylamine
  4. RCRA waste number U194


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		720 µg severe UCDS** 8/12/1968
skin
rabbit 		100 µg/24 hour open irritation test severe AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 2,500 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lethal concentration (50 percent kill): 2,500 mg/m3/2 hour N/R 85GMAT -,102,1982
inhalation
rat 		lethal concentration (50 percent kill): 2,310 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea

Liver: Hepatitis (hepatocellular necrosis), diffuse 		AEHLAU 1,343,1960
intraperitoneal
rat 		lowest published lethal dose: 37,500 µg/kg N/R FATOAO 31,238,1968
oral
rat 		lethal dose (50 percent kill): 370 mg/kg N/R NTIS** OTS0535430
skin
rabbit 		lethal dose (50 percent kill): 400 mg/kg N/R NTIS** OTS0535430
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 580 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 400 ppm/7 hour/50 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AEHLAU 1,343,1960


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (12 mg/m3), Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83632;
Number of Industries 3;
Total Number of Facilities 339;
Number of Occupations 7;
Total Number of Employees Exposed 1,723
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83632;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 28


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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