The Registry of Toxic Effects of Chemical Substances
Propionitrile, 2 - ( (4 - chloro - 6 - (ethylamino) - s - triazin - 2 - yl) amino) - 2 - methyl - |
UPDATE: August 2003 | MW: 240.73 | MF: C9H13ClN6 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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cytogenetic analysis
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human
lymphocyte
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1 mg/L
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MUREAV 281,295,1992
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dominant lethal test
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parenteral | Drosophila melanogaster
332 µmol/L
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JTEHD6 3,691,1977
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dominant lethal test
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oral | Drosophila melanogaster
100 ppm
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JTEHD6 3,691,1977
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DNA damage
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intraperitoneal | mouse
300 mg/kg
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MUREAV 493,1,2001
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morphological transform
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mouse
fibroblast
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50 mg/L
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EMMUEG 21,81,1993
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 250 mg/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Musculoskeletal system
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TJADAB 25(2),59A,1982
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oral | rat
lowest published toxic dose: 63 mg/kg (6-19 day pregnant)
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Reproductive: Other effects on female
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NNGADV 11,127,1986
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oral | rat
lowest published toxic dose: 250 mg/kg (6-15 day pregnant)
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Reproductive: Specific developmental abnormalities: Eye, ear
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RTOPDW 29,88,1999
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oral | rat
lowest published toxic dose: 1,612.8 mg/kg (72 day male/72 day prior to copulation)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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HBPTO* 1,714,2001
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oral | rat
lowest published toxic dose: 2,692.8 mg/kg (72 day male/72 day prior to copulation)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HBPTO* 1,714,2001
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oral | rat
lowest published toxic dose: 11.2 mg/kg (multigenerations)
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Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HBPTO* 1,714,2001
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oral | rabbit
lowest published toxic dose: 52 mg/kg (6-18 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Eye, ear
RTOPDW 29,88,1999
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 910 mg/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Skin and Appendages: Tumors
JTEHF8 60,567,2000
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oral | rat
lowest published toxic dose: 1,825 mg/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lethal concentration (50 percent kill): 2,470 mg/m3/4 hour
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N/R
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NNGADV 11,127,1986
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inhalation | rat
lowest published lethal concentration: >4,900 mg/m3
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Behavioral: Somnolence (general depressed activity) | Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974
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inhalation | rat
lethal concentration (50 percent kill): >960 mg/m3/4 hour
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N/R
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HBPTO* 1,709,2001
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inhalation | rat
lethal concentration (50 percent kill): 906 mg/m3
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Gastrointestinal: Nausea or vomiting
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HBPTO* 1,709,2001
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intraperitoneal | mouse
lethal dose (50 percent kill): 174 mg/kg
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N/R
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NNGADV 11,127,1986
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intraperitoneal | rat
lethal dose (50 percent kill): 112 mg/kg
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N/R
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NNGADV 11,127,1986
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oral | chicken
lethal dose (50 percent kill): 750 mg/kg
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Ear: Change in acuity | Behavioral: Somnolence (general depressed activity)
PSSCBG 5,153,1974
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oral | duck
lethal dose (50 percent kill): >2 gm/kg
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N/R
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PEMNDP 9,192,1991
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oral | dog
lowest published toxic dose: 5 mg/kg
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Endocrine: Adrenal cortex hypoplasia
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HBPTO* 1,710,2001
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oral | mouse
lethal dose (50 percent kill): 380 mg/kg
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N/R
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28ZEAL 5,62,1976
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oral | quail
lethal dose (50 percent kill): 400 mg/kg
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N/R
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PEMNDP 9,192,1991
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oral | rat
lethal dose (50 percent kill): 149 mg/kg
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N/R
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85ARAE 2,132,1977
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oral | rabbit
lethal dose (50 percent kill): 141 mg/kg
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N/R
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85DPAN -,-,1971/1976
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subcutaneous | mouse
lethal dose (50 percent kill): 3,715 mg/kg
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N/R
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NNGADV 11,127,1986
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subcutaneous | rat
lethal dose (50 percent kill): 1,738 mg/kg
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N/R
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NNGADV 11,127,1986
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skin | mouse
lethal dose (50 percent kill): >6,590 mg/kg
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N/R
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NNGADV 11,127,1986
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skin | rat
lethal dose (50 percent kill): 1,200 mg/kg
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N/R
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28ZEAL 5,62,1976
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skin | rabbit
lethal dose (50 percent kill): >2 gm/kg
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Behavioral: Somnolence (general depressed activity) | Lung, Thorax, or Respiration: Dyspnea
PSSCBG 5,153,1974
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | dog
lowest published toxic dose: 1,365 mg/kg/13 week- continuous
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
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oral | dog
lowest published toxic dose: 3,650 mg/kg/2 year- continuous
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Liver: Changes in liver weight | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
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oral | dog
lowest published toxic dose: 912.5 mg/kg/2 year- intermittent
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Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
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oral | dog
lowest published toxic dose: 1,095 mg/kg/1 year- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 1,710,2001
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oral | dog
lowest published toxic dose: 2,044 mg/kg/1 year- continuous
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Cardiac: Changes in heart weight | Liver: Changes in liver weight Endocrine: Changes in adrenal weight
HBPTO* 1,710,2001
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oral | dog
lowest published toxic dose: 1,022 mg/kg/1 year- continuous
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Lung, Thorax, or Respiration: Changes in lung weight | Kidney, Ureter, and Bladder: Changes in kidney weight
HBPTO* 1,710,2001
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oral | dog
lowest published toxic dose: 2,730 mg/kg/52 week- intermittent
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Blood: Other changes
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HBPTO* 2,1512,2001
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oral | mouse
lowest published toxic dose: 6,825 mg/kg/13 week- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 1,710,2001
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oral | mouse
lowest published toxic dose: 1,095 mg/kg/2 year- continuous
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Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
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oral | mouse
lowest published toxic dose: 27,375 mg/kg/2 year- continuous
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Endocrine: Hypoglycemia | Skin and Appendages: Other: Hair Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HBPTO* 1,710,2001
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oral | mouse
lowest published toxic dose: 109,500 mg/kg/2 year- continuous
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Cardiac: Cardiomyopathy including infarction | Skin: After systemic exposure: Dermatitis, other
HBPTO* 1,710,2001
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oral | mouse
lowest published toxic dose: 27,375 mg/kg/2 year- continuous
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Cardiac: Cardiomyopathy including infarction | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HBPTO* 1,710,2001
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oral | mouse
lowest published toxic dose: 1,970 mg/kg/78 week- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 2,1514,2001
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oral | rat
lowest published toxic dose: 273 mg/kg/13 week- continuous
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Behavioral: Food intake (animal) | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 11,127,1986
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oral | rat
lowest published toxic dose: 365.4 mg/kg/371 day- continuous
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Behavioral: Food intake (animal) | Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) Tumorigenic: Carcinogenic by RTECS criteria
JTEHD6 60,567,2000
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oral | rat
lowest published toxic dose: 508.3 mg/kg/371 day- continuous
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Behavioral: Food intake (animal)
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JTEHD6 60,567,2000
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oral | rat
lowest published toxic dose: 730 mg/kg/2 year- continuous
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Behavioral: Excitement | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,710,2001
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oral | rat
lowest published toxic dose: 73,000 mg/kg/2 year- continuous
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Endocrine: Tumors | Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 1,710,2001
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oral | rat
lowest published toxic dose: 1,346.4 mg/kg/72 day- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 1,714,2001
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oral | rat
lowest published toxic dose: 146,000 mg/kg/2 year- continuous
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Related to Chronic Data: Changes in testicular weight
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HBPTO* 1,714,2001
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oral | rat
lowest published toxic dose: 1,350 mg/kg/90 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 2,1512,2001
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oral | rat
lowest published toxic dose: 730 mg/kg/2 year- continuous
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain
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HBPTO* 2,1514,2001
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oral | rat
lowest published toxic dose: 730 mg/kg/2 year- continuous
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Behavioral: Euphoria
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HBPTO* 2,1514,2001
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: RED Completed
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RBREV* -,106,1998
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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|
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss; N crassa-aneuploidy
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EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
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EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss
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EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
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Used for preemergence or postemergence weed control in field corn
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
28ZEAL
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"Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
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85ARAE
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"Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77
revision
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85DPAN
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"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin,
Verlag Paul Parey, 1971-1976
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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HBPTO*
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Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
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JTEHF8
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Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd.,
Suite G, Levittown, PA 19057) V.53- 1998-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NNGADV
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Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku
Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
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PEMNDP
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Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4
7QG, UK) V.1- 1968-
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PSSCBG
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Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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RTOPDW
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Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1981-
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TJADAB
|
Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
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