The Registry of Toxic Effects of Chemical Substances
Propionitrile RTECS #: UF9625000
CAS #: 107-12-0
The Registry of Toxic Effects of Chemical Substances
Propionitrile |
| UPDATE: April 2002 | MW: 55.09 | MF: C3H5N |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
100 mg/24 hour
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moderate
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85JCAE -,898,1986
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skin | rabbit
500 mg/24 hour
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mild
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85JCAE -,898,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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sex chromosome loss and nondisjunction
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inhalation | Drosophila melanogaster
51 ppm
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MUREAV 259,165,1991
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sex chromosome loss and nondisjunction
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Saccharomyes cerevisiae
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15,100 mg/L
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MUREAV 224,31,1989
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 20,365,1993
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inhalation | rat
lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant)
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Reproductive: Specific developmental abnormalities: Urogenital system
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FAATDF 20,365,1993
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intraperitoneal | hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant)
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Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 23,317,1981
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intraperitoneal | hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant)
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Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 23,325,1981
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intraperitoneal | hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant)
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Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 23,325,1981
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oral | rat
lowest published toxic dose: 1,120 mg/kg (6-19 day pregnant)
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Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 7,33,1986
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oral | rat
lowest published toxic dose: 180 mg/kg (10 day pregnant)
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Reproductive: Other effects to embryo or fetus
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TXAPA9 163,149,2000
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lethal concentration (50 percent kill): 163 ppm/1 hour
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Liver: Other changes
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CTOXAO 18,991,1981
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inhalation | rat
lowest published lethal concentration: 500 ppm/4 hour
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N/R
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AMIHBC 4,119,1951
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intraperitoneal | guinea pig
lethal dose (50 percent kill): 10 mg/kg
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N/R
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38MKAJ 2C,4872,1982
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intraperitoneal | mouse
lethal dose (50 percent kill): 28 mg/kg
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Eye: Corneal damage | Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea
TXAPA9 59,589,1981
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intraperitoneal | rat
lethal dose (50 percent kill): 25 mg/kg
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N/R
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38MKAJ 2C,4872,1982
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intravenous | rabbit
lowest published lethal dose: 50 mg/kg
|
N/R
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CRSBAW 1,251,1889
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oral | guinea pig
lethal dose (50 percent kill): 25 mg/kg
|
N/R
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38MKAJ 2C,4872,1982
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oral | mouse
lethal dose (50 percent kill): 35,797 µg/kg
|
N/R
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NEZAAQ 39,423,1984
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oral | rat
lethal dose (50 percent kill): 39 mg/kg
|
N/R
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AMIHBC 4,119,1951
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subcutaneous | frog
lowest published lethal dose: 8 gm/kg
|
Behavioral: Tremor | Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
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subcutaneous | guinea pig
lethal dose (50 percent kill): 18,100 µg/kg
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Behavioral: Tremor | Behavioral: Muscle contraction or spasticity Gastrointestinal: Nausea or vomiting
MELAAD 47,192,1956
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subcutaneous | rabbit
lowest published lethal dose: 60 mg/kg
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Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation
AIPTAK 5,161,1899
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skin | guinea pig
lowest published lethal dose: 5 gm/kg
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N/R
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38MKAJ 2C,4872,1982
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skin | rabbit
lethal dose (50 percent kill): 210 µL/kg
|
N/R
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AMIHBC 4,119,1951
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unreported route | dog
lowest published lethal dose: 50 mg/kg
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N/R
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CRSBAW 1,251,1889
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 209 ppm/6 hour/14 week- intermittent
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Kidney, Ureter, and Bladder: Other changes in urine composition | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 5,113,1985
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPIONITRILE-air
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10 hour time-weighted average 6 ppm
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a solvent in petroleum refining, raw material for drug manufacture, setting agent
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8903
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
38MKAJ
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"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton,
eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd
rev. ed. in 1985.
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85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIPTAK
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Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of
Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
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AMIHBC
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AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU.
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CRSBAW
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Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.1- 1849-
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CTOXAO
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Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
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FAATDF
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Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1-40, 1981-97. For publisher information, see TOSCF2
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MELAAD
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Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16-
1925-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NEZAAQ
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Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto
Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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TJADAB
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Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
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TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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