The Registry of Toxic Effects of Chemical Substances

Propionic anhydride

RTECS #: UF9100000

CAS #: 123-62-6

UPDATE: June 1998 MW: 130.16 MF: C6H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Anhydrid kyseliny propionove (Czech)
  2. Methylacetic anhydride
  3. Propanoic anhydride
  1. Propionic acid anhydride
  2. Propionyl oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		510 mg open irritation test moderate UCDS** 12/15/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 2,360 mg/kg N/R AMIHBC 10,61,1954
skin
guinea pig 		lethal dose (50 percent kill): 1 mL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0533570
skin
rabbit 		lethal dose (50 percent kill): 10 mL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1181;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 66
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1181;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 2;
Total Number of Employees Exposed 489;
Total Number of Female Employees Exposed 32


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an esterifying and dehydrating agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as an esterifying and dehydrating agent

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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