The Registry of Toxic Effects of Chemical Substances

Propionic acid, 2 - ( (4 - chloro - o - tolyl) oxy) -

RTECS #: UE9750000

CAS #: 93-65-2

UPDATE: August 2003 MW: 214.66 MF: C10H11ClO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acide 2 - (4 - chloro - 2 - methyl - phenoxy) propionique (French)
  2. Acido 2 - (4 - cloro - 2 - metil - fenossi) - propionico (Italian)
  3. Anicon B
  4. Anicon P
  5. 2 - (4 - Chloor - 2 - methyl - fenoxy) - propionzuur (Dutch)
  6. 2 - (4 - Chlor - 2 - methyl - phenoxy) - propionsaeure (German)
  7. 2 - (4 - Chloro - 2 - methylphenoxy) propanoic acid
  8. alpha - (4 - Chloro - 2 - methylphenoxy) propionic acid
  9. 4 - Chloro - 2 - methylphenoxy - alpha - propionic acid
  10. 2 - (p - Chloro - o - tolyloxy) propionic acid
  11. CMPP
  12. Compitox
  13. FBC CMPP
  14. Liranox
  15. 2M - 4CP
  16. MCPP
  17. Mechlorprop
  18. Mecomec
  1. Mecoprop
  2. Mecoturf
  3. alpha - (2 - Methyl - 4 - chlorophenoxy) propionic acid
  4. 2 - Methyl - 4 - chlorophenoxy - alpha - propionic acid
  5. 2 - (2 - Methyl - 4 - chlorphenoxy) - propionsaeure (German)
  6. 2M 4KhP
  7. Morogal
  8. Okultin MP
  9. Propanoic acid, 2 - (4 - chloro - 2 - methylphenoxy) -
  10. Celatox CMPP
  11. Isocarnox
  12. Kilprop
  13. Kwas 4 - chloro - 2 - metylofenoksypropionowy (Polish)
  14. Kyselina 2 - (4 - chlor - 2 - methylfenoxy) propionova (Czech)
  15. Proponex - plus
  16. Rankotex
  17. SYS 67 Mecmin
  18. U 46 KV Fluid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition oral
mouse 		100 mg/kg MUREAV 55,197,1978
gene conversion and mitotic recombination Saccharomyes cerevisiae 742 ppm MUREAV 21,83,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 7 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARZNAD 33,1479,1983
oral
mouse 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARZNAD 33,1479,1983
oral
mouse 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ARZNAD 33,1479,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 402 mg/kg N/R TXCYAC 3,349,1975
oral
mouse 		lethal dose (50 percent kill): 369 mg/kg N/R RPZHAW 31,373,1980
oral
rat 		lethal dose (50 percent kill): 650 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 900 mg/kg N/R PCOC** -,683,1966
unreported route
mouse 		lethal dose (50 percent kill): 650 mg/kg N/R 30ZDA9 -,173,1971
unreported route
quail 		lethal dose (50 percent kill): >500 mg/kg N/R FMCHA2 -,C193,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 14,400 mg/kg/90 day- intermittent Behavioral: Food intake (animal)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 3,349,1975
skin
rabbit 		lowest published toxic dose: 15 gm/kg/3 week- intermittent Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 3,349,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,357,1986
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,156,1987
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
JTCTDW 38,111,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Unsupported RBREV* -,127,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4007;
Number of Industries 2;
Total Number of Facilities 40;
Number of Occupations 2;
Total Number of Employees Exposed 104
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4007;
Number of Industries 1;
Total Number of Facilities 263;
Number of Occupations 1;
Total Number of Employees Exposed 1,578


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to control many broadleaf weeds
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used to control many broadleaf weeds

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 7085-19-0
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