The Registry of Toxic Effects of Chemical Substances

Propionic acid, butyl ester

RTECS #: UE8245000

CAS #: 590-01-2

UPDATE: July 2002 MW: 130.21 MF: C7H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Propanoic acid, butyl ester (9CI)
  2. Butyl propanoate
  1. Butyl propionate
  2. n - Butyl propionate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe ATDAEI 1,192,1992
skin
rabbit 		500 mg/24 hour moderate FCTXAV 18,661,1980


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 5 gm/kg N/R FCTXAV 18,661,1980
skin
rabbit 		lethal dose (50 percent kill): >14 gm/kg N/R ATDAEI 1,192,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 3,200 ppm/6 hour/11 day- intermittent Olfaction: Change in olfactory nerve

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition 		NTIS** OTS0557952
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/13 week- intermittent Olfaction: Change in sensation of smell

Olfaction: Other olfaction effects 		TOPADD 27,618,1999
inhalation
rat 		lowest published toxic concentration: 800 ppm/2 week- intermittent Behavioral: Food intake (animal)

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHF8 61,79,2000
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/1 week- intermittent Behavioral: Food intake (animal) JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 750 ppm/6 hour/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 750 ppm/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Olfaction: Other olfaction effects 		JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 750 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/10 day- intermittent Eye: Lacrimation

Ear: Tumors 		JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/6 hour/10 day- intermittent Musculoskeletal: Other changes JTEHD6 61,79,2000
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/10 day- intermittent Behavioral: Food intake (animal) JTEHD6 61,79,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-

RTECS Compound Description:
   Primary Irritant

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