The Registry of Toxic Effects of Chemical Substances

Propionanilide, 3',4' - dichloro -

RTECS #: UE4900000

CAS #: 709-98-8

UPDATE: November 2003 MW: 218.09 MF: C9H9Cl2NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Propanex
  2. Propanid
  3. Propanide
  4. Propanil
  5. BAY 30130
  6. Cekupropanil
  7. Chem Rice
  8. Crystal propanil - 4
  9. DCPA
  10. 3,4 - Dichloranilid kyseliny propionove (Czech)
  11. N - (3,4 - Dichlorophenyl) propanamide
  12. N - (3,4 - Dichlorophenyl) propionamide
  13. 3',4' - Dichlorophenylpropionanilide
  14. Dichloropropionanilide
  15. 3,4 - Dichloropropionanilide
  16. 3',4' - Dichloropropionanilide
  17. Dipram
  18. DPA
  19. Farmco propanil
  20. FW 734
  1. Grascide
  2. Herbax technical
  3. Montrose propanil
  4. Propanamide, N - (3,4 - dichlorophenyl) -
  5. Propionic acid 3,4 - dichloroanilide
  6. Prop - Job
  7. Riselect
  8. Rogue
  9. Rosanil
  10. S 10165
  11. Stam
  12. Stam F 34
  13. Stam LV 10
  14. Stam M - 4
  15. Stampede
  16. Stampede 3E
  17. Stam supernox
  18. Strel
  19. Surcopur
  20. Synpran N


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		100 mg/kg CYGEDX 14(6),38,1980
DNA repair Bacillus subtilis 100 µg/disc NTIS** PB80-133226
specific locus test Drosophila melanogaster 0.5 mmol/L EMMUEG 36,40,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 50 mg/kg Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		HBPTO* 1,777,2001
oral
dog 		lethal dose (50 percent kill): 1,217 mg/kg Brain and Coverings: Recordings from specific areas of CNS TXAPA9 23,650,1972
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 2,527 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		NTIS** PB288-416
oral
mouse 		lethal dose (50 percent kill): 360 mg/kg N/R GTPZAB 21(12),30,1977
oral
rat 		lethal dose (50 percent kill): 367 mg/kg N/R KHZDAN 27,451,1984
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FMCHA2 -,C251,1991
skin
rabbit 		lethal dose (50 percent kill): 4,830 mg/kg N/R 85JFAN A343,1983
unreported route
mammal (species unspecified) 		lowest published toxic dose: 100 mg/kg Immunological Including Allergic: Decrease in cellular immune response HBPTO* 1,777,2001
unreported route
rat 		lethal dose (50 percent kill): 1,300 mg/kg N/R 30ZDA9 -,124,1971
unreported route
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,124,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 5,600 µg/m3/4 hour/9 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight 		GISAAA 35(8),31,1970
inhalation
rat 		lowest published toxic concentration: 5,300 µg/m3/4 hour/21 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 35(8),31,1970
inhalation
rat 		lowest published toxic concentration: 5,600 µg/m3/4 hour/9 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight

Blood: Changes in other cell count (unspecified) 		GISAAA 35(8),31,1970
inhalation
rat 		lowest published toxic concentration: 7 µg/kg/24 hour/14 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 40(9),17,1975
oral
mammal (species unspecified) 		lowest published toxic dose: 86,913 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB288-416
oral
rat 		lowest published toxic dose: 6,600 mg/kg/6 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		KHZDAN 27,451,1984
oral
rat 		lowest published toxic dose: 15,015 mg/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia 		TXAPA9 23,650,1972
oral
rat 		lowest published toxic dose: 58,240 mg/kg/2 year- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells 		TXAPA9 23,650,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,145,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
Used as post-emergent herbicide for rice and spring wheat
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as post-emergent herbicide for rice and spring wheat

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

ALT CAS #: 11096-32-5
 Click Here for Additional Information about RTECS