The Registry of Toxic Effects of Chemical Substances
Propionaldehyde, 2 - methyl - 2 - (methylthio) - , O - (methylcarbamoyl) oxime |
UPDATE: February 2005 | MW: 190.29 | MF: C7H14N2O2S |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | human lymphocyte | 350 mg/L | MUREAV 191,99,1987 |
DNA repair | Salmonella typhimurium | 1 mg/disc | JPFCD2 21,319,1986 |
mutation in microorganisms | mouse lymphocyte | 500 mg/L (+enzymatic activation step) | EMMUEG 12(Suppl 13),103,1988 |
mutation in mammalian somatic cells | human lymphocyte | 2 gm/L | MUREAV 196,61,1988 |
mutation in mammalian somatic cells | mouse lymphocyte | 839 mg/L | EMMUEG 12(Suppl 13),37,1988 |
morphological transform | rat embryo | 117 µg/plate | JJATDK 1,190,1981 |
sister chromatid exchange | human lymphocyte | 10 mg/L | MUREAV 138,175,1984 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 200 mg/m3/5 hour | N/R | 85JCAE -,999,1986 |
intraperitoneal mammal (species unspecified) | lowest published toxic dose: 1,000 ppb |
Blood: Changes in cell count (unspecified) Immunological Including Allergic: Decrease in cellular immune response | HBPTO* 1,776,2001 |
intraperitoneal rat | lethal dose (50 percent kill): 280 µg/kg | N/R | TSCAT* FYI-OTS-0885-0443 |
intravenous rat | lethal dose (50 percent kill): 470 µg/kg | N/R | TSCAT* FYI-OTS-0885-0443 |
oral wild bird | lethal dose (50 percent kill): 750 µg/kg | N/R | ASTTA8 (680),157,1979 |
oral chicken | lethal dose (50 percent kill): 8 mg/kg | N/R | 85GYAV -,62,1971 |
oral duck | lethal dose (50 percent kill): 3,400 µg/kg | N/R | TXAPA9 47,451,1979 |
oral domestic animal | lowest published lethal dose: 5 mg/kg |
Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Eye: Lacrimation | BVJOA9 146,358,1990 |
oral guinea pig | lethal dose (50 percent kill): 1 mg/kg | N/R | HBPTO* 2,1094,2001 |
oral human | lowest published toxic dose: 0.1 mg/kg | N/R | HBPTO* 2,1097,2001 |
oral human | lowest published toxic dose: 0.25 mg/kg |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1114,2001 |
oral human | lowest published toxic dose: 0.1 mg/kg | Autonomic Nervous System: Other (direct) parasympathomimetic | HBPTO* 2,1097,2001 |
oral man | lowest published toxic dose: 0.1 mg/kg |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1114,2001 |
oral mouse | lethal dose (50 percent kill): 300 µg/kg | N/R | JAFCAU 18,793,1970 |
oral pigeon | lethal dose (50 percent kill): 3,160 µg/kg | N/R | ASTTA8 (680),157,1979 |
oral quail | lethal dose (50 percent kill): 2 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | EESADV 8,551,1984 |
oral rat | lethal dose (50 percent kill): 0.46 mg/kg | N/R | HBPTO* 2,1094,2001 |
oral rat | lowest published toxic dose: 0.5 mg/kg |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1118,2001 |
oral rat | lowest published toxic dose: 0.5 mg/kg/45 minute |
Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1111,2001 |
oral rabbit | lethal dose (50 percent kill): 1.3 mg/kg | N/R | HBPTO* 2,1094,2001 |
oral woman | lowest published toxic dose: 28 mg/kg/10 day- intermittent |
Cardiac: Pulse rate decreased with fall in BP Gastrointestinal: Changes in structure or function of exocrine pancreas Nutritional and Gross Metabolic: Body temperature decrease | ICMED9 20,49,1994 |
subcutaneous mouse | lethal dose (50 percent kill): 250 µg/kg | N/R | TOIZAG 17,60,1970 |
subcutaneous rat | lethal dose (50 percent kill): 666 µg/kg | N/R | TXAPA9 25,569,1973 |
skin guinea pig | lethal dose (50 percent kill): 2,400 mg/kg | N/R | 85DPAN -,-,1971/1976 |
skin rat | lethal dose (50 percent kill): 2,500 µg/kg | N/R | TXAPA9 14,515,1969 |
skin rabbit | lethal dose (50 percent kill): 5.0 mg/kg | N/R | HBPTO* 2,1094,2001 |
unreported route rat | lethal dose (50 percent kill): 930 µg/kg | N/R | 30ZDA9 -,197,1971 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal rat | lowest published toxic dose: 8,400 µg/kg/21 day- intermittent |
Eye: Lacrimation Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands | DDREDK 24,343,1991 |
oral dog | lowest published toxic dose: 20.02 mg/kg/52 week- intermittent |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1113,2001 |
oral dog | lowest published toxic dose: 87.36 mg/kg/52 week- intermittent |
Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1113,2001 |
oral dog | lowest published toxic dose: 2.345 mg/kg/5 week- continuous |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1110,2001 |
oral domestic animal | lowest published toxic dose: 4 mg/kg/40 day- intermittent |
Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BVJOA9 146,358,1990 |
oral mouse | lowest published toxic dose: 4,500 µg/kg/15 day- intermittent |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | BECTA6 63,575,1999 |
oral rat | lowest published toxic dose: 437 mg/kg/2 year- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | RCTOE4 104,21,1988 |
oral rat | lowest published toxic dose: 1,440 mg/kg/120 day- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | PHTOEH 89,249,2001 |
oral rat | lowest published toxic dose: 14.4 gm/kg/120 day- intermittent |
Behavioral: Change in motor activity (specific assay) Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | PHTOEH 89,249,2001 |
oral rat | lowest published toxic dose: 144 gm/kg/120 day- intermittent |
Behavioral: Change in psychophysiological tests Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | PHTOEH 89,249,2001 |
oral rat | lowest published toxic dose: 365 mg/kg/2 year- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1113,2001 |
oral rat | lowest published toxic dose: 1.095 gm/kg/2 year- continuous | Eye: Other eye effects | HBPTO* 2,1113,2001 |
oral rat | lowest published toxic dose: 1.095 gm/kg/2 year- continuous |
Eye: Other eye effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1113,2001 |
oral rat | lowest published toxic dose: 46.5 mg/kg/93 day- continuous |
Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1110,2001 |
oral rat | lowest published toxic dose: 1.4 mg/kg/4 week- intermittent |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1112,2001 |
oral rat | lowest published toxic dose: 5.6 mg/kg/4 week- intermittent |
Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1112,2001 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 53,93,1991 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Available Data | IMEMDT 53,93,1991 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMEMDT 53,93,1991 |
TOXICOLOGY REVIEW |
| MUREAV 557,109,2004 |
TOXICOLOGY REVIEW |
| TOLED5 134,3,2002 |
TOXICOLOGY REVIEW |
| MUREAV 562,77,2004 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Supported | RBREV* -,82,1998 |
Occupational Exposure Limit - FINLAND | time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
N/R | N/R | N/R |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an agricultural chemical and pesticide | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-136,1979 |
OSHA ANALYTICAL METHOD #74 |
REFERENCES: | |
CODEN |
REFERENCE |
30ZDA9 | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 |
85DPAN | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 |
85GYAV | "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
ASTTA8 | ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- |
BECTA6 | Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- |
BVJOA9 | British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- |
DDREDK | Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- |
EESADV | Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
HBPTO* | Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 |
ICMED9 | Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
JAFCAU | Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- |
JJATDK | JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- |
JPFCD2 | Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NCITR* | National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. |
PHTOEH | Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
RCTOE4 | Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987- |
TOIZAG | Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TSCAT* | Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |