The Registry of Toxic Effects of Chemical Substances

Propionaldehyde, 2 - methyl - 2 - (methylthio) - , O - (methylcarbamoyl) oxime

RTECS #: UE2275000

CAS #: 116-06-3

UPDATE: February 2005 MW: 190.29 MF: C7H14N2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 2 - (methylthio) propanal, O - ( (methylamino) carbonyl) oxime
  2. 2 - Methyl - 2 - (methylthio) propionaldehyde O - (methylcarbamoyl) oxime
  3. 2 - Methyl - 2 - (methylthio) propionaldehyde O - methyl - carbamoyloxime
  4. 2 - Methyl - 2 - methylthio - propionaldehyd - O - (N - methyl - carbamoyl) - oxim (German)
  5. 2 - Metil - 2 - tiometil - propionaldeid - O - (N - metil - carbamoil) - ossima (Italian)
  6. AI3 - 27093
  7. Aldicarb
  8. Aldicarbe (French)
  9. Carbamic acid, methyl - , O - ( (2 - methyl - 2 - (methylthio) propylidene) amino) deriv.
  10. ENT 27,093
  1. NCI - C08640
  2. OMS - 771
  3. Propanal, 2 - methyl - 2 - (methylthio) - , O - ( (methylamino) carbonyl) oxime
  4. RCRA waste number P070
  5. TEMIK G
  6. Temik
  7. Temik 10 G
  8. Temik G10
  9. UC - 21149
  10. Union carbide UC - 21149


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 350 mg/L MUREAV 191,99,1987
DNA repair Salmonella typhimurium 1 mg/disc JPFCD2 21,319,1986
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in mammalian somatic cells human lymphocyte 2 gm/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 839 mg/L EMMUEG 12(Suppl 13),37,1988
morphological transform rat embryo 117 µg/plate JJATDK 1,190,1981
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 138,175,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 200 mg/m3/5 hour N/R 85JCAE -,999,1986
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 1,000 ppb Blood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response 		HBPTO* 1,776,2001
intraperitoneal
rat 		lethal dose (50 percent kill): 280 µg/kg N/R TSCAT* FYI-OTS-0885-0443
intravenous
rat 		lethal dose (50 percent kill): 470 µg/kg N/R TSCAT* FYI-OTS-0885-0443
oral
wild bird 		lethal dose (50 percent kill): 750 µg/kg N/R ASTTA8 (680),157,1979
oral
chicken 		lethal dose (50 percent kill): 8 mg/kg N/R 85GYAV -,62,1971
oral
duck 		lethal dose (50 percent kill): 3,400 µg/kg N/R TXAPA9 47,451,1979
oral
domestic animal 		lowest published lethal dose: 5 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Eye: Lacrimation 		BVJOA9 146,358,1990
oral
guinea pig 		lethal dose (50 percent kill): 1 mg/kg N/R HBPTO* 2,1094,2001
oral
human 		lowest published toxic dose: 0.1 mg/kg N/R HBPTO* 2,1097,2001
oral
human 		lowest published toxic dose: 0.25 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1114,2001
oral
human 		lowest published toxic dose: 0.1 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic HBPTO* 2,1097,2001
oral
man 		lowest published toxic dose: 0.1 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1114,2001
oral
mouse 		lethal dose (50 percent kill): 300 µg/kg N/R JAFCAU 18,793,1970
oral
pigeon 		lethal dose (50 percent kill): 3,160 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 2 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EESADV 8,551,1984
oral
rat 		lethal dose (50 percent kill): 0.46 mg/kg N/R HBPTO* 2,1094,2001
oral
rat 		lowest published toxic dose: 0.5 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1118,2001
oral
rat 		lowest published toxic dose: 0.5 mg/kg/45 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1111,2001
oral
rabbit 		lethal dose (50 percent kill): 1.3 mg/kg N/R HBPTO* 2,1094,2001
oral
woman 		lowest published toxic dose: 28 mg/kg/10 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Changes in structure or function of exocrine pancreas

Nutritional and Gross Metabolic: Body temperature decrease 		ICMED9 20,49,1994
subcutaneous
mouse 		lethal dose (50 percent kill): 250 µg/kg N/R TOIZAG 17,60,1970
subcutaneous
rat 		lethal dose (50 percent kill): 666 µg/kg N/R TXAPA9 25,569,1973
skin
guinea pig 		lethal dose (50 percent kill): 2,400 mg/kg N/R 85DPAN -,-,1971/1976
skin
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R TXAPA9 14,515,1969
skin
rabbit 		lethal dose (50 percent kill): 5.0 mg/kg N/R HBPTO* 2,1094,2001
unreported route
rat 		lethal dose (50 percent kill): 930 µg/kg N/R 30ZDA9 -,197,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 8,400 µg/kg/21 day- intermittent Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		DDREDK 24,343,1991
oral
dog 		lowest published toxic dose: 20.02 mg/kg/52 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1113,2001
oral
dog 		lowest published toxic dose: 87.36 mg/kg/52 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1113,2001
oral
dog 		lowest published toxic dose: 2.345 mg/kg/5 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1110,2001
oral
domestic animal 		lowest published toxic dose: 4 mg/kg/40 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BVJOA9 146,358,1990
oral
mouse 		lowest published toxic dose: 4,500 µg/kg/15 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		BECTA6 63,575,1999
oral
rat 		lowest published toxic dose: 437 mg/kg/2 year- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field RCTOE4 104,21,1988
oral
rat 		lowest published toxic dose: 1,440 mg/kg/120 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PHTOEH 89,249,2001
oral
rat 		lowest published toxic dose: 14.4 gm/kg/120 day- intermittent Behavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		PHTOEH 89,249,2001
oral
rat 		lowest published toxic dose: 144 gm/kg/120 day- intermittent Behavioral: Change in psychophysiological tests

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		PHTOEH 89,249,2001
oral
rat 		lowest published toxic dose: 365 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1113,2001
oral
rat 		lowest published toxic dose: 1.095 gm/kg/2 year- continuous Eye: Other eye effects HBPTO* 2,1113,2001
oral
rat 		lowest published toxic dose: 1.095 gm/kg/2 year- continuous Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1113,2001
oral
rat 		lowest published toxic dose: 46.5 mg/kg/93 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1110,2001
oral
rat 		lowest published toxic dose: 1.4 mg/kg/4 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1112,2001
oral
rat 		lowest published toxic dose: 5.6 mg/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1112,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,93,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,93,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,93,1991
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,82,1998
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical and pesticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-136,1979
OSHA ANALYTICAL METHOD #74


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949-
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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