RTECS:UD1800000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

1 - Propene, 1,1,3,3,3 - pentafluoro - 2 - trifluoromethyl -

RTECS #: UD1800000

CAS #: 382-21-8

UPDATE: November 2004 MW: 200.04 MF: C₄F₈

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Isobutene, octafluoro -

Octafluoro - sec - butene

Octafluoroisobutylene

PFIB

Perfluoroisobutylene

Perfluoroisobutylene (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
cat lowest published lethal concentration: 25 mg/m³/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia TLSMA6 75,221,1963
inhalation
cat lethal concentration (50 percent kill): 25 mg/m³/2 hour N/R VCVGH* -,296,1990
inhalation
guinea pig lethal concentration (50 percent kill): 1,050 ppb/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression BIMEA5 57,247,1968
inhalation
mouse lowest published lethal concentration: 10 mg/m³/2 hour Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage GTPZAB 5(3),3,1961
inhalation
mouse lethal concentration (50 percent kill): 15 mg/m³/2 hour N/R VCVGH* -,296,1990
inhalation
rat lethal concentration (50 percent kill): 500 ppb/6 hour N/R 34ZIAG -,310,1969
inhalation
rat lethal concentration (50 percent kill): 7.5 mg/m³/2 hour N/R VCVGH* -,296,1990
inhalation
rabbit lethal concentration (50 percent kill): 1,200 ppb/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression BIMEA5 57,247,1968
inhalation
rabbit lethal concentration (50 percent kill): 25 mg/m³/2 hour N/R VCVGH* -,296,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published toxic concentration: 1,500 痢/m³/6 hour/19 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning TLSMA6 75,221,1963

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.01 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.082 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.082 mg/m³, 2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
BIMEA5 Biologie Medicale (Paris). (Paris, France) 1903-75. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

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SYNONYMS:
Isobutene, octafluoro - Octafluoro - sec - butene Octafluoroisobutylene	PFIB Perfluoroisobutylene Perfluoroisobutylene (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation cat	lowest published lethal concentration: 25 mg/m³/2 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Ataxia	TLSMA6 75,221,1963
inhalation cat	lethal concentration (50 percent kill): 25 mg/m³/2 hour	N/R	VCVGH* -,296,1990
inhalation guinea pig	lethal concentration (50 percent kill): 1,050 ppb/2 hour	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	BIMEA5 57,247,1968
inhalation mouse	lowest published lethal concentration: 10 mg/m³/2 hour	Lung, Thorax, or Respiration: Emphysema Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Hemorrhage	GTPZAB 5(3),3,1961
inhalation mouse	lethal concentration (50 percent kill): 15 mg/m³/2 hour	N/R	VCVGH* -,296,1990
inhalation rat	lethal concentration (50 percent kill): 500 ppb/6 hour	N/R	34ZIAG -,310,1969
inhalation rat	lethal concentration (50 percent kill): 7.5 mg/m³/2 hour	N/R	VCVGH* -,296,1990
inhalation rabbit	lethal concentration (50 percent kill): 1,200 ppb/2 hour	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	BIMEA5 57,247,1968
inhalation rabbit	lethal concentration (50 percent kill): 25 mg/m³/2 hour	N/R	VCVGH* -,296,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published toxic concentration: 1,500 痢/m³/6 hour/19 week- intermittent	Brain and Coverings: Recordings from specific areas of CNS Behavioral: Alteration of classical conditioning	TLSMA6 75,221,1963

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	ceiling concentration 0.01 ppm	DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - DENMARK	time-weighted average 0.01 ppm (0.082 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC- continuous 0.082 mg/m³, 2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
34ZIAG	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
BIMEA5	Biologie Medicale (Paris). (Paris, France) 1903-75. Discontinued.
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TLSMA6	Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.