The Registry of Toxic Effects of Chemical Substances

2 - Propanone, 1 - chloro -

RTECS #: UC0700000

CAS #: 78-95-5

UPDATE: November 2004 MW: 92.53 MF: C3H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acetone, chloro -
  2. Acetonyl chloride
  3. A - Stoff
  4. Chloracetone (French)
  5. Chloroacetone
  6. Chloroacetone (ACGIH)
  7. 1 - Chloro - 2 - ketopropane
  1. 1 - Chloro - 2 - oxopropane
  2. Chloropropanone
  3. 1 - Chloro - 2 - propanone
  4. Monochloracetone
  5. Monochloroacetone
  6. Tonite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6 mg/L (+enzymatic activation step) MUREAV 341,1,1994
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		100 pph/6 minute PREBA3 62,284,1946/1947


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published lethal concentration: 605 ppm/10 minute N/R NTIS** PB214-270
inhalation
human 		lowest published toxic concentration: 18 mg/m3 Eye: Lacrimation VCVGK* -,439,1994
inhalation
rat 		lethal concentration (50 percent kill): 262 ppm/1 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		AIHAAP 47,375,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 92 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		OYYAA2 33,695,1987
intraperitoneal
rat 		lethal dose (50 percent kill): 80 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		OYYAA2 33,695,1987
oral
mouse 		lethal dose (50 percent kill): 127 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		AIHAAP 47,375,1986
oral
rat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		AIHAAP 47,375,1986
skin
guinea pig 		lethal dose (50 percent kill): 100 µL/kg N/R KODAK* 21MAY1971
skin
rabbit 		lethal dose (50 percent kill): 141 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		AIHAAP 47,375,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 650 mg/kg/17 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Gastritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570898


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 1 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3.8 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.8 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5194;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 4,354;
Total Number of Female Employees Exposed 729


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Mutagen
   Human Data

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