The Registry of Toxic Effects of Chemical Substances

Propene, 1,3 - dichloro -

RTECS #: UC8310000

CAS #: 542-75-6

UPDATE: May 2005 MW: 110.97 MF: C3H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichloro - 2 - propene
  2. 1,3 - Dichloropropene
  3. 1,3 - Dichloropropene (ACGIH)
  4. 1,3 - Dichloropropene, technical grade
  5. 1,3 - Dichloropropene - 1
  6. 1,3 - Dichloropropylene
  7. 3 - Chloroallyl chloride
  8. 3 - Chloropropenyl chloride
  9. D - D 92
  10. DD 95
  1. Dorlone II
  2. NCI - C03985
  3. RCRA waste number U084
  4. Telone
  5. Telone II
  6. Telone II soil fumigant
  7. alpha,gamma - Dichloropropylene
  8. alpha - Chloroallyl chloride
  9. gamma - Chloroallyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 49,100 µg/L EMMUEG 13,60,1989
DNA damage intraperitoneal
mouse 		150 mg/kg MUREAV 419,13,1998
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (-enzymatic activation step) ENMUDM 2,59,1980
mutation in mammalian somatic cells mouse lymphocyte 3 mg/L SCIEAS 236,933,1987
other mutation test systems Escherichia coli 1 mmol/L MUREAV 203,81,1988
sister chromatid exchange hamster ovary 900 nmol/L CNJGA8 22,681,1980
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5,750 ppm ENMUDM 7,325,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 60 ppm/6 hour/5 day/2 year Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		FAATDF 12,418,1989
oral
mouse 		lowest published toxic dose: 31,200 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Bladder tumors 		NTPTR* NTP-TR-269,1985
oral
mouse 		lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		NTIS** PB85-230449/AS
oral
mouse 		lowest published toxic dose: 31,200 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB85-230449/AS
oral
mouse 		lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NTIS** PB85-230449/AS
oral
rat 		lowest published toxic dose: 15,600 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NTPTR* NTP-TR-269,1985
oral
rat 		lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB85-230449/AS
oral
rat 		lowest published toxic dose: 7,800 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB85-230449/AS
oral
rat 		lowest published toxic dose: 7,800 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		NTIS** PB85-230449/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 400 ppm/7 hour N/R AIHAAP 38,217,1977
inhalation
human 		lowest published toxic concentration: 1,500 ppm Lung, Thorax, or Respiration: Cough VCVGH* -,474,1990
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 3.88 gm/m3 N/R FEREAC 65,1869,2000
inhalation
mouse 		lethal concentration (50 percent kill): 3,220 mg/m3/2 hour N/R VCVGH* -,473,1990
inhalation
rat 		lowest published lethal concentration: 1,000 ppm/2 hour Eye: Lacrimation AIHAAP 38,217,1977
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		CRTOEC 13,1096,2000
intraperitoneal
mouse 		lowest published lethal dose: 700 mg/kg N/R CRTOEC 13,1096,2000
intraperitoneal
rat 		lethal dose (50 percent kill): 175 mg/kg N/R TOXID9 5,2,1985
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 224 mg/kg N/R FEREAC 65,1869,2000
oral
mouse 		lethal dose (50 percent kill): 640 mg/kg N/R FAATDF 8,562,1987
oral
rat 		lethal dose (50 percent kill): 470 mg/kg N/R VCVGH* -,473,1990
skin
rat 		lethal dose (50 percent kill): 775 mg/kg N/R FMCHA2 -,C103,1991
skin
rabbit 		lethal dose (50 percent kill): 333 mg/kg N/R FEREAC 65,1869,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 90 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 11,207,1988
inhalation
rat 		lowest published toxic concentration: 90 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 11,207,1988
oral
dog 		lowest published toxic dose: 3,731 mg/kg/13 week- continuous Blood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		RTOPDW 30,233,1999
oral
dog 		lowest published toxic dose: 5,460 mg/kg/1 year- continuous Blood: Microcytosis with or without anemia

Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		RTOPDW 30,233,1999
oral
mouse 		lowest published toxic dose: 1,365 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 32,224,1996
oral
rat 		lowest published toxic dose: 455 mg/kg/26 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases 		GISAAA 39(1),94,1974
oral
rat 		lowest published toxic dose: 1,365 mg/kg/13 week- continuous Gastrointestinal: Alteration in gastric secretion

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 32,224,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,113,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,933,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,933,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,151,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (5 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (4.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND 1 ppm (5 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-DICHLOROPROPENE-air Carcinogen;
8 hour time-weighted average 1 ppm (Sk) 		NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3912;
Number of Industries 3;
Total Number of Facilities 48;
Number of Occupations 14;
Total Number of Employees Exposed 2,162;
Total Number of Female Employees Exposed 33


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110765/AS)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a soil fumigant prior to planting crops such as cotton, sugar beet, potatoes
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a soil fumigant prior to planting crops such as cotton, sugar beet, potatoes

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

ALT CAS #: 8022-76-2
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