The Registry of Toxic Effects of Chemical Substances

Propene, 3 - chloro - 2 - methyl -

RTECS #: UC8050000

CAS #: 563-47-3

UPDATE: May 2005 MW: 90.56 MF: C4H7Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Chloro - 2 - methyl - 2 - propene
  2. 2 - Methallyl chloride
  3. 2 - Methyl - 2 - propenyl chloride
  4. 2 - Methyl - allylchlorid (German)
  5. 2 - Methylallyl chloride
  6. 3 - Chlor - 2 - methyl - prop - 1 - en (German)
  7. 3 - Chloro - 2 - methyl - 1 - propene
  8. 3 - Chloro - 2 - methylpropene
  9. 3 - Chloro - 2 - methylpropene (IUPAC)
  10. 3 - Chloroisobutylene
  1. 3 - Cloro - 2 - metil - prop - 1 - ene (Italian)
  2. Chlorure de methallyle (French)
  3. Cloruro di metallile (Italian)
  4. Isobutenyl chloride
  5. Methallyl chloride
  6. Methyl allyl chloride
  7. NCI - C54820
  8. beta - Methallyl chloride
  9. beta - Methylallyl chloride
  10. gamma - Chloroisobutylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 200 mg/L NTPTR* NTP-TR-300,1986
unscheduled DNA synthesis human HeLa cell 1 mmol/L CALEDQ 20,263,1983
mutation in microorganisms Salmonella typhimurium 6 µmol/plate (+/-enzymatic activation step) BCPCA6 29,2611,1980
mutation in mammalian somatic cells mouse lymphocyte 23,200 µg/L SCIEAS 236,933,1987
sister chromatid exchange hamster ovary 16 mg/L EMMUEG 13,133,1989
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		4,500 ppm EMMUEG 23,208,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Eye: Tumors 		INHEAO 38,309,2000
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-300,1986
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		PAACA3 26,95,1985
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB86-247293/AS
oral
rat 		lowest published toxic dose: 77,250 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTPTR* NTP-TR-300,1986
oral
rat 		lowest published toxic dose: 38,625 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		PAACA3 26,95,1985
oral
rat 		toxic dose : 77,250 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		NTPTR* NTP-TR-300,1986
oral
rat 		lowest published toxic dose: 38,625 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB86-247293/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published lethal concentration: 22,000 ppm/10 minute N/R 34ZIAG -,377,1969
inhalation
mouse 		lethal concentration (50 percent kill): 7,000 mg/m3/2 hour N/R VCVGH* -,497,1990
inhalation
rat 		lethal concentration (50 percent kill): 34 gm/m3/30 minute N/R FAVUAI 7,35,1975
oral
cat 		lethal dose (50 percent kill): 750 mg/kg N/R VCVGH* -,497,1990
oral
mouse 		lowest published lethal dose: 3,160 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Blood: Changes in spleen 		NTPTR* NTP-TR-300,1986
oral
mouse 		lethal dose (50 percent kill): 1,370 mg/kg N/R VCVGH* -,497,1990
oral
rat 		lethal dose (50 percent kill): 848 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage 		NTIS** OTS0539687
oral
rat 		lethal dose (50 percent kill): 580 mg/kg N/R VCVGH* -,497,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 16 gm/m3/1 hour/5 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JOHYAY 46,217,1948
oral
mouse 		lowest published toxic dose: 10,500 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-300,1986
oral
mouse 		lowest published toxic dose: 81,250 mg/kg/13 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-300,1986
oral
rat 		lowest published toxic dose: 7 gm/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-300,1986
oral
rat 		lowest published toxic dose: 19,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-300,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 63,325,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,325,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 63,325,1995
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83971;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 2;
Total Number of Employees Exposed 1,683


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an agricultural chemical and pesticide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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