The Registry of Toxic Effects of Chemical Substances

2 - Propen - 1 - amine, N - 2 - propenyl -

RTECS #: UC6650000

CAS #: 124-02-7

UPDATE: July 2000 MW: 97.18 MF: C6H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Di - 2 - propenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg/20S rinse severe AEHLAU 1,343,1960
skin
rabbit 		100 µg/24 hour open irritation test severe AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 2,100 mg/m3 N/R TPKVAL 14,80,1975
inhalation
man 		lowest published toxic concentration: 5 ppm/5 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		AEHLAU 1,343,1960
inhalation
rat 		lethal concentration (50 percent kill): 795 ppm/8 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		AEHLAU 1,343,1960
intraperitoneal
mouse 		lethal dose (50 percent kill): 187 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes 		AEHLAU 1,343,1960
oral
mouse 		lethal dose (50 percent kill): 355 mg/kg N/R 85GMAT -,43,1982
oral
rat 		lethal dose (50 percent kill): 578 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		AEHLAU 1,343,1960
skin
rabbit 		lethal dose (50 percent kill): 280 µL/kg N/R AIHAAP 23,95,1962
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 350 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ppm/7 hour/50 day- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		AEHLAU 1,343,1960


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TXCYAC 44,129,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

NIOSH PROFILE (AMINES, SECONDARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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