RTECS:UB8785000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

2 - Propanol, 1,1' - oxydi -

RTECS #: UB8785000

CAS #: 110-98-5

UPDATE: February 2003 MW: 134.20 MF: C₆H₁₄O₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Bis (2 - hydroxypropyl) ether

2,2' - Dihydroxydipropyl ether

2,2' - Dihydroxyisopropyl ether

1,1' - Dimethyldiethylene glycol

Dipropylene glycol

Dipropylenglykol (Czech)

NIAX catalyst D - 19

1,1' - Oxydi - 2 - propanol

2 - Propanol, 1,1' - oxybis - (9CI)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 500 mg mild AJOPAA 29,1363,1946
skin
rabbit 500 無/24 hour moderate NTIS OTS0535986

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
intraperitoneal
mouse lethal dose (50 percent kill): 4,494 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FEPRA7 6,342,1947
intraperitoneal
rat lethal dose (50 percent kill): 10 gm/kg N/R FCTXAV 16,729,1978
intravenous
dog lethal dose (50 percent kill): 11,500 mg/kg Behavioral: Antipsychotic FCTXAV 16,729,1978
intravenous
rat lethal dose (50 percent kill): 5,800 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor AMIHBC 3,448,1951
oral
guinea pig lethal dose (50 percent kill): 17,600 無/kg N/R GWXXBX #2703360
oral
rat lethal dose (50 percent kill): 14,800 mg/kg N/R VCVGK* -,157,1984
skin
rabbit lethal dose (50 percent kill): >20 mL/kg N/R UCDS 12/17/1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JACTDZ 4(5),223,1985

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9011;
Number of Industries 12;
Total Number of Facilities 184;
Number of Occupations 13;
Total Number of Employees Exposed 3,536;
Total Number of Female Employees Exposed 1,385

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent in inks, extraction of aromatics, and preparation of plasticizers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent in inks, extraction of aromatics, and preparation of plasticizers and resins

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
Primary Irritant

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SYNONYMS:
Bis (2 - hydroxypropyl) ether 2,2' - Dihydroxydipropyl ether 2,2' - Dihydroxyisopropyl ether 1,1' - Dimethyldiethylene glycol Dipropylene glycol	Dipropylenglykol (Czech) NIAX catalyst D - 19 1,1' - Oxydi - 2 - propanol 2 - Propanol, 1,1' - oxybis - (9CI)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	500 mg	mild	AJOPAA 29,1363,1946
skin rabbit	500 無/24 hour	moderate	NTIS** OTS0535986

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 4,494 mg/kg	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	FEPRA7 6,342,1947
intraperitoneal rat	lethal dose (50 percent kill): 10 gm/kg	N/R	FCTXAV 16,729,1978
intravenous dog	lethal dose (50 percent kill): 11,500 mg/kg	Behavioral: Antipsychotic	FCTXAV 16,729,1978
intravenous rat	lethal dose (50 percent kill): 5,800 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Behavioral: Tremor	AMIHBC 3,448,1951
oral guinea pig	lethal dose (50 percent kill): 17,600 無/kg	N/R	GWXXBX #2703360
oral rat	lethal dose (50 percent kill): 14,800 mg/kg	N/R	VCVGK* -,157,1984
skin rabbit	lethal dose (50 percent kill): >20 mL/kg	N/R	UCDS** 12/17/1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		JACTDZ 4(5),223,1985

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X9011; Number of Industries 12; Total Number of Facilities 184; Number of Occupations 13; Total Number of Employees Exposed 3,536; Total Number of Female Employees Exposed 1,385

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent in inks, extraction of aromatics, and preparation of plasticizers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AJOPAA	American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7	Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GWXXBX	German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JACTDZ	Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.