The Registry of Toxic Effects of Chemical Substances

1 - Propanol, 2,3 - dibromo - , phosphate (3:1)

RTECS #: UB0350000

CAS #: 126-72-7

UPDATE: May 2005 MW: 697.67 MF: C9H15Br6O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (2,3 - Dibromopropyl) phosphate
  2. 2,3 - Dibromo - 1 - propanol phosphate
  3. APEX 462 - 5
  4. Anfram 3PB
  5. Bromkal P 67 - 6HP
  6. ES685
  7. Firemaster LV - T 23P
  8. Firemaster T23P
  9. Firemaster T23P - LV
  10. Flacavon R
  11. Flamex T 23P
  12. Flammex AP
  13. Flammex LV - T 23P
  14. Flammex T 23P
  15. Fyrol HB32
  16. NCI - C03270
  1. Phosphoric acid, tris (2,3 - dibromopropyl) ester
  2. RCRA waste number U235
  3. T 23P
  4. TDBP
  5. TDBP (Czech)
  6. TDBPP
  7. Tris (flame retardant)
  8. Tris (2,3 - dibromopropyl) phosphate
  9. Tris (2,3 - dibromopropyl) phosphoric acid ester
  10. Tris (2,3 - dibromopropyl) phosphate
  11. Tris (dibromopropyl) phosphate
  12. Tris - (2,3 - dibrompropyl) fosfat (Czech)
  13. Tris - 2,3 - dibrompropyl ester kyseliny fosforecne (Czech)
  14. Tris - BP
  15. USAF DO - 41
  16. Zetifex ZN


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,1137,1986
skin
rabbit 		2 mg/24 hour severe 85JCAE -,1137,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium 		50 mg/kg JEPTDQ 3(1-2),207,1979
body fluid assay rat
Salmonella typhimurium 		500 mg/kg CTOXAO 17,101,1980
cytogenetic analysis hamster lung 100 mg/L AMONDS 3,253,1980
cytogenetic analysis intravenous
mouse 		1,500 mg/kg MUREAV 60,329,1979
cytogenetic analysis mouse lymphocyte 10 mg/L JEPTDQ 3(1-2),207,1979
DNA damage human other cell types 2 mg/L MUREAV 56,89,1977
DNA damage intraperitoneal
rat 		2,500 nmol/L CBINA8 82,195,1992
DNA damage rat liver 10 µmol/L CBINA8 82,195,1992
DNA repair Escherichia coli 10 µg/plate MUREAV 74,107,1980
unscheduled DNA synthesis rat liver 50 µmol/L MUREAV 124,213,1983
mutation in microorganisms Escherichia coli 100 µg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms hamster lung 20 µmol/L (+enzymatic activation step) APTOA6 56,20,1985
mutation in microorganisms mouse lymphocyte 25 mg/L (+enzymatic activation step) JEPTDQ 3(1-2),207,1979
mutation in microorganisms Salmonella typhimurium 2,270 µg/plate (+enzymatic activation step) MUREAV 57,381,1978
mutation in microorganisms Salmonella typhimurium 110 nmol/plate (-enzymatic activation step) MUTAEX 2,287,1987
micronucleus test intraperitoneal
hamster 		400 mg/kg EJCODS 18,1337,1982
micronucleus test intraperitoneal
mouse 		1,020 mg/kg JJIND8 66,691,1981
micronucleus test intraperitoneal
rat 		250 µmol/kg CRNGDP 15,1197,1994
mutation in mammalian somatic cells hamster lung 20 µmol/L MUREAV 124,213,1983
mutation in mammalian somatic cells oral
mouse 		1,200 mg/kg/4 day- continuous EMMUEG 28,342,1996
mutation in mammalian somatic cells mouse lymphocyte 5 ppm MUREAV 53,160,1978
morphological transform hamster embryo 25 mg/L EJCODS 18,1337,1982
morphological transform mouse lymphocyte 2,500 µg/L JEPTDQ 3(1-2),207,1979
morphological transform rat embryo 1,270 ng/plate JJATDK 1,190,1981
sister chromatid exchange parenteral
chicken 		424 µg/kg 47JMAE -,137,1982
sister chromatid exchange hamster lung 5 mg/L JNCIAM 60,1179,1978
sister chromatid exchange human embryo 69,700 µg/L SNSHBT (20),574,1980
sister chromatid exchange intravenous
mouse 		1,500 mg/kg MUREAV 60,329,1979
sister chromatid exchange mouse lymphocyte 5 mg/L JEPTDQ 3(1-2),207,1979
sister chromatid exchange mouse lung 125 mg/kg JNCIAM 60,1179,1978
sex chromosome loss and nondisjunction unreported route
Drosophila melanogaster 		1,000 ppm JEPTDQ 3(1-2),207,1979
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		500 ppm ENMUDM 1,144,1979
specific locus test oral
Drosophila melanogaster 		250 µmol/L CRNGDP 15,1197,1994
specific locus test oral
rat 		12.5 gm/kg/45 day- continuous EMMUEG 36,1,2000
sperm morphology intraperitoneal
mouse 		4,085 mg/kg/5 day- intermittent JJIND8 66,691,1981
heritable translocation test oral
Drosophila melanogaster 		1,000 ppm/2 day- continuous MUREAV 57,385,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 8,510 mg/kg (72 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JACTDZ 5(2),153,1986
intraperitoneal
rat 		lowest published toxic dose: 4,260 mg/kg (72 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands JACTDZ 5(2),153,1986
oral
rat 		lowest published toxic dose: 1,800 mg/kg (7-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina ESKHA5 (98),50,1980
oral
rat 		lowest published toxic dose: 250 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTXAV 19,67,1981
oral
rat 		lowest published toxic dose: 450 mg/kg (7-15 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) JTSCDR 4,296,1979
oral
rat 		lowest published toxic dose: 1,800 mg/kg (7-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTSCDR 8,339,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 39 gm/kg/92 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NCITR* NCI-TR-76,1978
oral
mouse 		toxic dose : 87 gm/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NCITR* NCI-TR-76,1978
oral
mouse 		toxic dose : 43 gm/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NCITR* NCI-TR-76,1978
oral
rat 		lowest published toxic dose: 1,330 mg/kg/76 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-76,1978
oral
rat 		toxic dose : 3,600 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-76,1978
oral
rat 		toxic dose : 1,800 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-76,1978
oral
rat 		toxic dose : 1,820 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		FCTXAV 18,743,1980
oral
rat 		toxic dose : 43,680 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		FCTXAV 18,743,1980
oral
rat 		toxic dose : 26 gm/kg/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Colon tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		LAINAW 44,74,1981
skin
mouse 		lowest published toxic dose: 85 gm/kg/71 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors 		CNREA8 38,3236,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 6,800 mg/kg Behavioral: Excitement GTPZAB 29(12),53,1985
oral
rat 		lethal dose (50 percent kill): 810 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes 		SRTCAC 36(1-4),10,1989
skin
rabbit 		lethal dose (50 percent kill): >8 gm/kg N/R FRCHD6 1,205,1974
unreported route
mouse 		lethal dose (50 percent kill): 1,149 mg/kg N/R JJIND8 66,691,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition 		JJATDK 7,23,1987
skin
rabbit 		lowest published toxic dose: 29,510 mg/kg/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Changes in testicular weight 		JTEHD6 3,979,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,575,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,905,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,369,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,905,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,905,1999
TOXICOLOGY REVIEW
ENVRAL 13,74,1977
TOXICOLOGY REVIEW
CTOXAO 17,101,1980


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1916;
Number of Industries 2;
Total Number of Facilities 18;
Number of Occupations 7;
Total Number of Employees Exposed 206


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman; In vivo SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a flame retardant additive for synthetic textiles and plastics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-76,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed., Totowa, NJ, Allanheld, Osmun & Co., 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FRCHD6 JFF/Fire Retardant Chemistry. (Technomic Pub. Co., Inc., 265 W. State St., Westport, CN 06880) V.1- 1974-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1952-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976.
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-

Used as a flame retardant additive for synthetic textiles and plastics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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