The Registry of Toxic Effects of Chemical Substances

Propane, 1,2,3 - trichloro -

RTECS #: TZ9275000

CAS #: 96-18-4

UPDATE: May 2005 MW: 147.43 MF: C3H5Cl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Trichloropropane
  2. 1,2,3 - Trichloropropane (ACGIH:OSHA)
  3. Allyl trichloride
  4. Glycerol trichlorohydrin
  1. Glyceryl trichlorohydrin
  2. NCI - C60220
  3. Trichlorohydrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL moderate NTIS** OTS0534994
skin
rabbit 		500 µL/24 hour mild NTIS** OTS0534994


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis inhalation
rat 		800 µg/L BEXBAN 78,1414,1974
DNA damage human lymphocyte 2 mmol/L MUREAV 371,185,1996
DNA damage intraperitoneal
rat 		55,361 µg/kg CRTOEC 4,528,1991
mutation in microorganisms Salmonella typhimurium 500 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 3),15,1985
sister chromatid exchange hamster lung 300 µmol/L ENMUDM 9,401,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 400 mg/kg (5 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) MUREAV 101,321,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,120 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NTPTR* NTP-TR-384,1993
oral
mouse 		lowest published toxic dose: 3,120 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NTIS** PB94-207784
oral
mouse 		lowest published toxic dose: 31,200 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Tumors 		NTIS** PB94-207784
oral
rat 		lowest published toxic dose: 5,200 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NTPTR* NTP-TR-384,1993
oral
rat 		lowest published toxic dose: 1,560 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB94-207784
oral
rat 		lowest published toxic dose: 15,600 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Reproductive: Other reproductive system tumors 		NTIS** PB94-207784
oral
rat 		lowest published toxic dose: 5,200 mg/kg/104 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Other reproductive system tumors 		NTIS** PB94-207784


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 3,400 mg/m3/2 hour N/R VCVGH* -,397,1990
inhalation
rat 		lowest published lethal concentration: 500 ppm/4 hour N/R UCDS** 3/20/1973
oral
dog 		lowest published lethal dose: 200 mg/kg Behavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		AJHYA2 16,325,1932
oral
guinea pig 		lethal dose (50 percent kill): 340 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes 		TKGMB8 124,27,1976
oral
mouse 		lethal dose (50 percent kill): 369 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes 		TKGMB8 124,27,1976
oral
rat 		lethal dose (50 percent kill): 108 µL/kg Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes

Skin and Appendages: Other: Hair 		NTIS** OTS0534994
oral
rabbit 		lethal dose (50 percent kill): 380 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Other changes 		TKGMB8 124,27,1976
skin
rabbit 		lethal dose (50 percent kill): 372 µL/kg Gastrointestinal: Hypermotility, diarrhea

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		NTIS** OTS0534994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 3,210 mg/m3/5 hour/23 day- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGH* -,398,1990
inhalation
rat 		lowest published toxic concentration: 297 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in ovarian weight 		JTEHD6 25,299,1988
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/24 hour/94 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 42(8),50,1977
inhalation
rat 		lowest published toxic concentration: 15 ppm/6 hour/13 week- intermittent Eye: Lacrimation

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0542010
oral
mouse 		lowest published toxic dose: 5,355 mg/kg/17 week- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		NTPTR* NTP-TR-384,1993
oral
rat 		lowest published toxic dose: 2,720 mg/kg/17 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		NTPTR* NTP-TR-384,1993
oral
rat 		lowest published toxic dose: 1,179 mg/kg/10 day- intermittent Cardiac: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		JJATDK 11,179,1991
unreported route
rat 		lowest published toxic dose: 3,210 mg/m3/90 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGH* -,398,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,223,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,223,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 63,223,1995
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,151,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (300 mg/m3) DTLVS* 3,266,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (60 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (60 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (60 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (300 mg/m3), short term exposure limit 75 ppm (450 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.108 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (306 mg/m3), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2,3-TRICHLOROPROPANE-air Carcinogen;
10 hour time-weighted average 10 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 73960;
Number of Industries 4;
Total Number of Facilities 108;
Number of Occupations 5;
Total Number of Employees Exposed 490
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 73960;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 7;
Total Number of Employees Exposed 492;
Total Number of Female Employees Exposed 10


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110872/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as paint and varnish remover, solvent and degreasing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9216
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TKGMB8 Trudy Khar'kovskogo Meditsinskogo Instituta. (Khar'kovskii Gosudarstvennyi Meditsinskii Institut, Kharkov, USSR) N.1- 1935-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as paint and varnish remover, solvent and degreasing agent

NIOSH PROFILE (1,2,3-TRICHLOROPROPANE), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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