The Registry of Toxic Effects of Chemical Substances

Propane, 2,2' - oxybis -

RTECS #: TZ5425000

CAS #: 108-20-3

UPDATE: November 2004 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Isopropoxypropane
  2. Diisopropyl oxide
  3. Ether isopropylique (French)
  4. Ether, isopropyl
  1. Isopropyl ether
  2. Isopropyl ether (ACGIH:OSHA)
  3. Izopropylowy eter (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		363 mg open irritation test mild UCDS** 4/10/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 3,095 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTEHD6 49,29,1996
inhalation
rat 		lowest published toxic concentration: 10,000 mg/m3 (10 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) VCVGK* -,266,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
guinea pig 		lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
inhalation
human 		lowest published toxic concentration: 1,250 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,267,1994
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 130 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
monkey 		lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
monkey 		lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
inhalation
mouse 		lethal concentration (50 percent kill): 131 gm/m3 Behavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		GTPZAB 19(10),55,1975
inhalation
mouse 		lethal concentration (50 percent kill): 130,800 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
rat 		lethal concentration (50 percent kill): 162 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		GTPZAB 19(10),55,1975
inhalation
rat 		lethal concentration (50 percent kill): 161,700 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
rabbit 		lethal concentration (50 percent kill): 121 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		GTPZAB 19(10),55,1975
inhalation
rabbit 		lethal concentration (50 percent kill): 120,600 mg/m3 Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
rabbit 		lowest published lethal concentration: 6 pph Behavioral: General anesthetic

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,266,1994
inhalation
rabbit 		lowest published toxic concentration: 3 pph Behavioral: General anesthetic VCVGK* -,266,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 812 mg/kg N/R SCCUR* -,5,1961
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 6 gm/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 3,600 mg/kg N/R VCVGK* -,266,1994
oral
rat 		lethal dose (50 percent kill): 5,880 mg/kg N/R VCVGK* -,266,1994
oral
rabbit 		lowest published lethal dose: 6 gm/kg Behavioral: Altered sleep time (including change in righting reflex) JIHTAB 21(3),72,1939
skin
rabbit 		lethal dose (50 percent kill): 20 mL/kg N/R UCDS** 4/10/1968
unreported route
mouse 		lethal dose (50 percent kill): 3,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		GTPZAB 19(10),55,1975
unreported route
rat 		lethal dose (50 percent kill): 5,880 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		GTPZAB 19(10),55,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,090 mg/m3/5 hour/22 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes 		GTPZAB 19(10),55,1975
inhalation
rat 		lowest published toxic concentration: 3,300 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		JTEHD6 49,29,1996
inhalation
rat 		lowest published toxic concentration: 7,500 mg/m3/30 day- intermittent Behavioral: Irritability

Brain and Coverings: Increased intracranial pressure 		VCVGK* -,266,1994
inhalation
rat 		lowest published toxic concentration: 10,000 mg/m3/4 hour/10 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		VCVGK* -,266,1994
inhalation
rat 		lowest published toxic concentration: 2,090 mg/m3/5 hour/152 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired 		VCVGK* -,267,1994
inhalation
rabbit 		lowest published toxic concentration: 2,090 mg/m3/5 hour/22 week- intermittent Behavioral: Muscle contraction or spasticity

Liver: Liver function tests impaired 		GTPZAB 19(10),55,1975
inhalation
rabbit 		lowest published toxic concentration: 2,090 mg/m3/5 hour/152 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Blood: Changes in spleen 		VCVGK* -,267,1994
inhalation
rabbit 		lowest published toxic concentration: 507 mg/m3/5 hour/152 day- intermittent Liver: Multiple effects VCVGK* -,267,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 250 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 250 ppm;short term exposure limit 310 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 310 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (1050 mg/m3) DTLVS* 3,142,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (2100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 250 ppm (1050 mg/m3), short term exposure limit 310 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 250 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1300 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 250 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 250 ppm (1050 mg/m3) JAN1999
Occupational Exposure Limit - GERMANY MAK 500 ppm (2100 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 125 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 250 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2100 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 250 ppm (1060 mg/m3), short term exposure limit 310 ppm, Sep2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 310 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 310 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL ETHER-air 10 hour time-weighted average 500 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25905;
Number of Industries 11;
Total Number of Facilities 952;
Number of Occupations 11;
Total Number of Employees Exposed 12,024
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25905;
Number of Industries 5;
Total Number of Facilities 130;
Number of Occupations 11;
Total Number of Employees Exposed 3,253;
Total Number of Female Employees Exposed 1,126


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent or as an additive for gasolines
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl ether, 1618


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent or as an additive for gasolines

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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