The Registry of Toxic Effects of Chemical Substances

Propane, 2 - nitro -

RTECS #: TZ5250000

CAS #: 79-46-9

UPDATE: May 2005 MW: 89.11 MF: C3H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - NP
  2. 2 - Nitropropane
  3. 2 - Nitropropane (ACGIH:OSHA)
  4. Dimethylnitromethane
  5. Isonitropropane
  6. Nipar S - 20
  1. Nipar S - 20 solvent
  2. Nipar S - 30 solvent
  3. Nitroisopropane
  4. RCRA waste number U171
  5. beta - Nitropropane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 60 mmol/L MUREAV 190,217,1987
DNA damage oral
rat 		44,555 µg/kg CALEDQ 57,61,1991
DNA damage intraperitoneal
rat 		100 mg/kg MUREAV 391,165,1997
DNA damage Salmonella typhimurium 50 mg/L MUREAV 104,49,1982
DNA repair domestic animal other cell types 2 mmol/L MUREAV 413,69,1998
DNA repair intraperitoneal
rat 		20 mg/kg CRNGDP 9,811,1988
DNA repair rat liver 30 µmol/L CRNGDP 9,811,1988
unscheduled DNA synthesis rat liver 1 µmol/L MUREAV 221,263,1989
unscheduled DNA synthesis intraperitoneal
rat 		20 mg/kg CRNGDP 9,811,1988
unscheduled DNA synthesis oral
rat 		50 mg/kg CRNGDP 10,2329,1989
mutation in microorganisms Escherichia coli 2,500 µg/plate (+/-enzymatic activation step) SAIGBL 29,34,1987
mutation in microorganisms Salmonella typhimurium 25 µmol/L (+enzymatic activation step) FAATDF 13,341,1989
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
micronucleus test oral
rat 		25 mg/kg CRNGDP 10,2329,1989
sister chromatid exchange human lymphocyte 7,500 µmol/L MUREAV 190,217,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 2,550 mg/kg (1-15 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TXAPA9 48,A35,1979
intraperitoneal
rat 		lowest published toxic dose: 2,550 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		SWEHDO 7(Suppl 4),66,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 207 ppm/7 hour/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JEPTDQ 2(5),233,1979
inhalation
rat 		toxic concentration (other than lowest) : 207 ppm/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		XPHCI* 25APR1977
oral
rat 		lowest published toxic dose: 4,277 mg/kg/16 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CRNGDP 8,1947,1987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 714 ppm/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHBC 5,52,1952
inhalation
guinea pig 		lowest published lethal concentration: 4,622 ppm/5 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		AMIHBC 5,52,1952
inhalation
man 		lowest published toxic concentration: 20 ppm Behavioral: Anorexia (human)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		INMEAF 16,441,1947
inhalation
mouse 		lethal concentration (50 percent kill): 10 gm/m3/2 hour N/R 85GMAT -,94,1982
inhalation
rat 		lethal concentration (50 percent kill): 400 ppm/6 hour N/R JEPTDQ 2(5),233,1979
inhalation
rabbit 		lowest published lethal concentration: 2,381 ppm/5 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		AMIHBC 5,52,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 75 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat 		lowest published lethal dose: 1,100 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia BSPLA9 (2),83,1972
oral
rat 		lethal dose (50 percent kill): 720 mg/kg N/R 34ZIAG -,430,1969
oral
rabbit 		lowest published lethal dose: 500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		JIHTAB 22,315,1940


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 29,331,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1079,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 29,331,1982
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1079,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1079,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (90 mg/m3) DTLVS* 3,188,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (18 mg/m3), TGV 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.036 mg/m3, 2003
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (19 mg/m3), Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-NITROPROPANE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 51090;
Number of Industries 57;
Total Number of Facilities 2,335;
Number of Occupations 42;
Total Number of Employees Exposed 29,842
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 51090;
Number of Industries 15;
Total Number of Facilities 345;
Number of Occupations 19;
Total Number of Employees Exposed 9,818;
Total Number of Female Employees Exposed 1,817


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for polymers and as stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 17, 1977
NIOSH Analytical Method, 1994: 2-Nitropropane, 2528
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #46
OSHA ANALYTICAL METHOD #15, SUPERSEDED BY #46


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BSPLA9 Bulletin de la Societe de Pharmacie de Lille. (Societe de Pharmacie du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch) V.1- 1945-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
XPHCI* U.S. Public Health Service, Current Intelligence Bulletin. (National Institute for Occupational Safety and Health, 5600 Fishers Lane, Rockville, MD 20857)

Used as solvent for polymers and as stabilizer

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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