The Registry of Toxic Effects of Chemical Substances

Propane, 1 - nitro -

RTECS #: TZ5075000

CAS #: 108-03-2

UPDATE: November 2004 MW: 89.11 MF: C3H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - NP
  2. 1 - Nitropropane
  1. 1 - Nitropropane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		150 ppm/15 minute N/R JIHTAB 28,262,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 1 µmol/L MUREAV 221,263,1989
sister chromatid exchange hamster ovary 74 mg/L/24 hour (-enzymatic activation step) MUREAV 515,181,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 5,000 ppm/3 hour N/R JIHTAB 22,315,1940
inhalation
human 		lowest published toxic concentration: 150 ppm Eye: Conjunctiva irritation JIHTAB 28,262,1946
inhalation
rat 		lethal concentration (50 percent kill): 3,100 ppm/8 hour N/R NPIRI* 1,91,1974
inhalation
rabbit 		lethal concentration (50 percent kill): 5,000 ppm/3 hour N/R 85JCAE -,404,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R KHFZAN 10(6),53,1976
intraperitoneal
rat 		lowest published lethal dose: 550 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia BSPLA9 (4),131,1972
oral
mouse 		lethal dose (50 percent kill): 800 mg/kg Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement 		GISAAA 32(9),9,1967
oral
rat 		lethal dose (50 percent kill): 455 mg/kg N/R NPIRI* 1,91,1974
oral
rabbit 		lowest published lethal dose: 250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		JIHTAB 22,315,1940
skin
rabbit 		lethal dose : >2 gm/kg N/R NTIS** OTS0556802


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,800 mg/kg/4 week- continuous Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0556802


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (90 mg/m3) DTLVS* 3,188,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (90 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (90 mg/m3), short term exposure limit 40 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 25 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 90 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (18 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (93 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-NITROPROPANE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 51100;
Number of Industries 20;
Total Number of Facilities 1,155;
Number of Occupations 31;
Total Number of Employees Exposed 9,874
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 51100;
Number of Industries 19;
Total Number of Facilities 2,539;
Number of Occupations 26;
Total Number of Employees Exposed 21,537;
Total Number of Female Employees Exposed 1,311


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for polymers and as stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #46


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BSPLA9 Bulletin de la Societe de Pharmacie de Lille. (Societe de Pharmacie du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch) V.1- 1945-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as solvent for polymers and as stabilizer

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS