The Registry of Toxic Effects of Chemical Substances
Propanenitrile, 2 - methyl - RTECS #: TZ4900000
CAS #: 78-82-0
The Registry of Toxic Effects of Chemical Substances
Propanenitrile, 2 - methyl - |
| UPDATE: January 1997 | MW: 69.12 | MF: C4H7N |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
skin | rabbit
380 mg open irritation test
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mild
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UCDS** 10/29/1959
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
|
N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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inhalation | rat
lowest published lethal concentration: 1,000 ppm/4 hour
|
N/R
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AIHAAP 23,95,1962
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intraperitoneal | mouse
lethal dose (50 percent kill): 25 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea
ZAARAM 19,225,1969
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oral | mouse
lethal dose (50 percent kill): 25 mg/kg
|
N/R
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ARTODN 55,47,1984
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oral | rat
lethal dose (50 percent kill): 50 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Muscle weakness Vascular: Regional or general arteriolar or venous dilation
38MKAJ 2C,4874,1982
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oral | rabbit
lethal dose (50 percent kill): 14 mg/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea
ZAARAM 19,225,1969
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subcutaneous | frog
lowest published lethal dose: 4,800 mg/kg
|
Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
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subcutaneous | rabbit
lowest published lethal dose: 9 mg/kg
|
Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Hypermotility, diarrhea
AIPTAK 5,161,1899
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skin | guinea pig
lowest published lethal dose: 5 gm/kg
|
N/R
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38MKAJ 2C,4874,1982
|
skin | rabbit
lethal dose (50 percent kill): 200 mg/kg
|
N/R
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ZAARAM 19,225,1969
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
N/R
|
N/R
|
N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYRONITRILE-air
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10 hour time-weighted average 8 ppm
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NIOSH* DHHS #92-100,1992
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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REFERENCES:
CODEN
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REFERENCE
38MKAJ
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"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton,
eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd
rev. ed. in 1985.
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AIHAAP
|
American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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AIPTAK
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Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of
Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
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ARTODN
|
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
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NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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UCDS**
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Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
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ZAARAM
|
Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25,
1951-75.
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