The Registry of Toxic Effects of Chemical Substances

Propane, 1,2 - epoxy - 3 - phenoxy -

RTECS #: TZ3675000

CAS #: 122-60-1

UPDATE: May 2004 MW: 150.19 MF: C9H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (Phenoxymethyl) oxirane
  2. 1,2 - Epoxy - 3 - phenoxypropane
  3. 2,3 - Epoxypropylphenyl ether
  4. 3 - Phenoxy - 1,2 - epoxypropane
  5. Ageflex PGE
  6. Benzene, (2,3 - epoxypropoxy) -
  7. Ether, 2,3 - epoxypropyl phenyl
  8. Ether, phenylglycidyl
  9. Fenyl - glycidylether (Czech)
  10. Glycidyl phenyl ether
  11. Heloxy WC - 63
  1. Oxirane, (phenoxymethyl) -
  2. PGE (OSHA)
  3. Phenol glycidyl ether
  4. Phenol - glycidaether (German)
  5. Phenoxypropene oxide
  6. Phenoxypropylene oxide
  7. Phenyl 2,3 - epoxypropyl ether
  8. Phenyl glycidyl ether
  9. Phenyl glycidyl ether (ACGIH:OSHA)
  10. Phenylglycydyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		111 mg mild AMIHAB 14,250,1956
eye
rabbit 		250 µg/24 hour severe 85JCAE -,776,1986
skin
rabbit 		10 mg/24 hour open irritation test severe AMIHBC 10,61,1954
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,776,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
host-mediated assay mouse
Salmonella typhimurium 		2,500 mg/kg MUREAV 67,9,1979
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Klebsiella pneumoniae 100 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) MUREAV 67,9,1979
morphological transform hamster embryo 6,250 µg/L MUREAV 67,9,1979
other mutation test systems Escherichia coli 300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 400 µmol/L MUREAV 249,55,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 11 ppm/6 hour (19 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 64,204,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 12 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		AJPAA4 111,140,1983
inhalation
rat 		lowest published toxic concentration: 1,092 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		TOXID9 72,27,2003
inhalation
rat 		lowest published toxic concentration: 728 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		TOXID9 72,27,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >100 ppm/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956
inhalation
rat 		lethal concentration (50 percent kill): >100 ppm/8 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
rat 		lethal dose (50 percent kill): 3,850 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		AMIHAB 14,250,1956
subcutaneous
mouse 		lethal dose (50 percent kill): 760 mg/kg Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic) ARZNAD 15,1355,1965
skin
rabbit 		lethal dose (50 percent kill): 1,500 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 ppm/6 hour/90 day- intermittent Skin and Appendages: Other: Hair JTEHD6 3,859,1977
inhalation
rat 		lowest published toxic concentration: 728 mg/kg/2 year- intermittent Olfaction: Other olfaction effects TOXID9 72,27,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin, sen) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 47,237,1989
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1525,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1525,1999
TOXICOLOGY REVIEW
AJOGAH 113,130,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (62 mg/m3) DTLVS* 3,206,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (60 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (6.1 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (60 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (62 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.6 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 10 ppm (60 mg/m3), KTV 15 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (6 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (6.2 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL GLYCIDYL ETHER-air Carcinogen ceiling concentration 1 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57280;
Number of Industries 13;
Total Number of Facilities 434;
Number of Occupations 12;
Total Number of Employees Exposed 8,533
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57280;
Number of Industries 15;
Total Number of Facilities 355;
Number of Occupations 18;
Total Number of Employees Exposed 10,551;
Total Number of Female Employees Exposed 4,108


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used to increase storage time and stability of halogenated compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: Phenyl glycidyl ether, 1619


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to increase storage time and stability of halogenated compounds

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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