The Registry of Toxic Effects of Chemical Substances

Propane, 1,2 - epoxy - 3 - isopropoxy -

RTECS #: TZ3500000

CAS #: 4016-14-2

UPDATE: November 2004 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ( (1 - Methylethoxy) methyl) oxirane
  2. (Isopropoxymethyl) oxirane
  3. 1,2 - Epoxy - 3 - isopropoxypropane
  4. 2,3 - Epoxypropyl isopropyl ether
  5. 3 - Isopropyloxypropylene oxide
  6. Glycidyl isopropyl ether
  1. IGE (OSHA)
  2. Isopropyl epoxypropyl ether
  3. Isopropyl glycidyl ether
  4. Isopropyl glycidyl ether (ACGIH:OSHA)
  5. NCI - C56439
  6. Oxirane, ( (1 - methylethoxy) methyl) - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		92 mg moderate AMIHAB 14,250,1956
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,772,1986
skin
rabbit 		459 mg/3 day moderate AMIHAB 14,250,1956
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,772,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) MUREAV 172,105,1986
other mutation test systems Escherichia coli 3,300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 2,500 µmol/L MUREAV 249,55,1991
specific locus test oral
Drosophila melanogaster 		2,900 ppm EMMUEG 23,51,1994
heritable translocation test oral
Drosophila melanogaster 		2,900 ppm EMMUEG 23,51,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,500 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		AMIHAB 14,250,1956
inhalation
rat 		lethal concentration (50 percent kill): 1,100 ppm/8 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		AMIHAB 14,250,1956
oral
mouse 		lethal dose (50 percent kill): 1,300 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
rat 		lethal dose (50 percent kill): 4,200 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
skin
rabbit 		lethal dose (50 percent kill): 9,650 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 400 ppm/7 hour/10 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHAB 14,250,1956


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 75 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 75 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (240 mg/m3) DTLVS* 3,142,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (238 mg/m3), short term exposure limit 75 ppm (356 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m3), KZG- week 100 ppm (480 mg/m3),JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 30 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (241 mg/m3), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 75 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 75 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL GLYCIDYL ETHER-air ceiling concentration 50 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: Isopropyl glycidyl ether, 1620


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS