The Registry of Toxic Effects of Chemical Substances

Propane, 1,2 - epoxy -

RTECS #: TZ2975000

CAS #: 75-56-9

UPDATE: May 2005 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. AD 6 (suspending agent)
  2. Epoxypropane
  3. 1,2 - Epoxypropane
  4. 1,2 - Epoxypropane (ACGIH:OSHA)
  5. 2,3 - Epoxypropane
  6. Ethylene oxide, methyl -
  7. Methyl ethylene oxide
  8. Methyloxacyclopropane
  9. Methyl oxirane
  1. NCI - C50099
  2. Oxirane, methyl -
  3. Oxyde de propylene (French)
  4. Propane, epoxy -
  5. Propene oxide
  6. Propylene epoxide
  7. Propylene oxide
  8. 1,2 - Propylene oxide
  9. Propylene oxide (DOT:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg severe AJOPAA 29,1363,1946
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,768,1986
skin
rabbit 		415 mg open irritation test moderate UCDS** 12/13/1963
skin
rabbit 		50 mg/6 minute severe AMIHAB 13,228,1956


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 160 mg/L SCIEAS 236,933,1987
cytogenetic analysis human lymphocyte 1,850 µg/L MUREAV 67,101,1979
cytogenetic analysis intraperitoneal
mouse 		349 mg/kg MUREAV 288,223,1993
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis rat liver 25 µg/L MUREAV 153,57,1985
cytogenetic analysis inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
dominant lethal test inhalation
rat 		300 ppm/5 day- intermittent MUREAV 117,337,1983
DNA adduct inhalation
Drosophila melanogaster 		2 ppm/24 hour MUREAV 529,95,2003
DNA adduct mammal (species unspecified) lymphocyte 100 mmol/tube CBINA8 67,275,1988
DNA adduct inhalation
rat 		600 mg/kg/4 week- intermittent CRNGDP 21,2011,2000
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
DNA damage mammal (species unspecified) lymphocyte 75 mmol/L CBINA8 9,97,1974
DNA damage intraperitoneal
mouse 		200 mg/kg MUREAV 467,83,2000
DNA damage other fish testis 5 gm ABBIA4 97,80,1962
DNA damage other microorganisms 1 mmol/L MUREAV 368,235,1996
DNA damage rat liver 30 µmol/L SinJF# 26OCT1982
DNA damage inhalation
rat 		25 ppm/3 day- intermittent TXAPA9 191,245,2003
DNA damage salmon sperm 5 mL ABBIA4 97,80,1962
mutation in microorganisms Escherichia coli 700 µg/plate (+/-enzymatic activation step) MUREAV 67,101,1979
mutation in microorganisms Klebsiella pneumoniae 500 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Neurospora crassa 500 mmol/L (-enzymatic activation step) GENTAE 40,890,1955
mutation in microorganisms other microorganisms 25 mmol/L (-enzymatic activation step) MUREAV 73,1,1980
mutation in microorganisms other microorganisms 5 mmol/plate (-enzymatic activation step) EMMUEG 23,274,1994
mutation in microorganisms Salmonella typhimurium 350 µg/plate (+enzymatic activation step) ABCHA6 47,2461,1983
mutation in microorganisms Salmonella typhimurium 700 µg/plate (-enzymatic activation step) MUREAV 67,101,1979
mutation in microorganisms Saccharomyes cerevisiae 50 mmol/L (-enzymatic activation step) MUREAV 250,229,1991
mutation in microorganisms Schizosaccharomyces pombe 183 mmol/L (-enzymatic activation step) ADWMAX -,193,1962
micronucleus test intraperitoneal
mouse 		600 mg/kg/24 hour MUREAV 67,101,1979
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L MUREAV 250,229,1991
mutation in mammalian somatic cells mouse lymphocyte 400 µg/L SCIEAS 236,933,1987
other mutation test systems Salmonella typhimurium 1 pph ENMUDM 9,171,1987
sister chromatid exchange hamster ovary 5 mg/L SCIEAS 236,933,1987
sister chromatid exchange hamster lung 2,500 µmol/L MUREAV 249,55,1991
sister chromatid exchange human lymphocyte 25,000 ppm ENMUDM 7(Suppl 3),48,1985
sister chromatid exchange intraperitoneal
mouse 		232 mg/kg MUREAV 288,223,1993
sister chromatid exchange Saccharomyes cerevisiae 100 mmol/L MUREAV 250,229,1991
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		645 ppm/24 hour- continuous MUREAV 117,337,1983
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		1 ppb EMMUEG 23,208,1994
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		10 ppb EMMUEG 23,208,1994
specific locus test inhalation
Drosophila melanogaster 		1,500 ppm MUREAV 405,259,1998
specific locus test inhalation
Drosophila melanogaster 		3.9 ppm/24 hour MUREAV 529,95,2003
specific locus test mouse lymphocyte 160 ppm/48 hour- continuous EMMUEG 17,122,1991
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
heritable translocation test parenteral
Drosophila melanogaster 		10 ppb EMMUEG 23,208,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lowest published toxic concentration: 100 ppm/7 hour (2 year male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 3,60,1983
inhalation
rat 		lowest published toxic concentration: 500 ppm/7 hour (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB83-258038
inhalation
rat 		lowest published toxic concentration: 500 ppm/7 hour (1-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) NTIS** PB83-258038
inhalation
rat 		lowest published toxic concentration: 500 ppm/7 hour (15 day prior to copulation/1-16 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility 		SWEHDO 9,94,1983
intraperitoneal
rat 		lowest published toxic dose: 47 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NEZAAQ 49,168,1994
intraperitoneal
rat 		lowest published toxic dose: 1,860 mg/kg (6 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NEZAAQ 49,168,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 400 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTPTR* NTP-TR-267,1985
inhalation
mouse 		lowest published toxic concentration: 400 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		JJIND8 77,573,1986
inhalation
mouse 		lowest published toxic concentration: 24,720 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTIS** PB85-179653/AS
inhalation
mouse 		lowest published toxic concentration: 24,720 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors 		NTIS** PB85-179653/AS
inhalation
rat 		lowest published toxic concentration: 100 ppm/7 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors 		TXAPA9 76,69,1984
inhalation
rat 		toxic concentration (other than lowest) : 400 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		JJIND8 77,573,1986
inhalation
rat 		toxic concentration (other than lowest) : 300 ppm/6 hour/2.3 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		FCTOD7 26,159,1988
inhalation
rat 		lowest published toxic concentration: 12,360 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors 		NTIS** PB85-179653/AS
inhalation
rat 		lowest published toxic concentration: 10,300 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors 		NTIS** PB85-179653/AS
oral
rat 		lowest published toxic dose: 10,798 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		BJCAAI 46,924,1982
oral
rat 		toxic dose : 2,714 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		BJCAAI 46,924,1982
subcutaneous
mouse 		lowest published toxic dose: 272 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
mouse 		toxic dose : 3,640 mg/kg/91 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		BJCAAI 39,588,1979
subcutaneous
mouse 		toxic dose : 868 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
mouse 		toxic dose : 2,912 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
mouse 		toxic dose : 6,616 mg/kg/95 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application 		ZHPMAT 174,383,1981
subcutaneous
rat 		lowest published toxic dose: 1,500 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens 		ANYAA9 68,750,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 2,005 ppm/4 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting 		AMIHAB 13,237,1956
inhalation
guinea pig 		lowest published lethal concentration: 4,000 ppm/4 hour Eye: Iritis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 13,228,1956
inhalation
man 		lowest published toxic concentration: 1,400 gm/m3/10 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		GTPZAB 15(2),48,1971
inhalation
mouse 		lethal concentration (50 percent kill): 1,740 ppm/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHAB 13,237,1956
inhalation
rat 		lethal concentration (50 percent kill): 4,000 ppm/4 hour Olfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 13,237,1956
intraperitoneal
mouse 		lethal dose (50 percent kill): 175 mg/kg N/R 85GMAT -,103,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 150 mg/kg N/R 85GMAT -,103,1982
oral
guinea pig 		lethal dose (50 percent kill): 660 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GISAAA 46(7),76,1981
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 440 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 440 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		GTPZAB 14(11),55,1970
oral
rat 		lethal dose (50 percent kill): 380 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		GTPZAB 14(11),55,1970
skin
rabbit 		lethal dose (50 percent kill): 1,500 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 457 ppm/7 hour/22 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHAB 13,228,1956
inhalation
mouse 		lowest published toxic concentration: 487 ppm/6 hour/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		NTPTR* NTP-TR-267,1985
inhalation
mouse 		lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-267,1985
inhalation
rat 		lowest published toxic concentration: 457 ppm/7 hour/28 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 13,228,1956
inhalation
rat 		lowest published toxic concentration: 1,433 ppm/6 hour/12 day- intermittent Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-267,1985
inhalation
rat 		lowest published toxic concentration: 25 mg/m3/4 hour/26 week- intermittent Brain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section 		GTPZAB 14(11),55,1970
inhalation
rat 		lowest published toxic concentration: 529 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects FAATDF 27,25,1995
inhalation
rat 		lowest published toxic concentration: 997 ppm/6 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* OTS0535203
oral
rat 		lowest published toxic dose: 1,170 mg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Other changes 		GISAAA 46(7),76,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (sen) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 36,227,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,181,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 36,227,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,181,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 60,181,1994
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TOLED5 140-141,53,2003
TOXICOLOGY REVIEW
MUREAV 5432012003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 580,91,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,204,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (240 mg/m3) DTLVS* 3,219,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (240 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (50 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (48 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (12 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (12 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 20 ppm (50 mg/m3), continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (12 mg/m3), KTV 10 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2.5 ppm (6 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (12 mg/m3), Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE OXIDE-air Carcinogen lowest feasible concentrtion NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 63550;
Number of Industries 78;
Total Number of Facilities 9,032;
Number of Occupations 60;
Total Number of Employees Exposed 75,135
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 63550;
Number of Industries 57;
Total Number of Facilities 5,786;
Number of Occupations 67;
Total Number of Employees Exposed 421,140;
Total Number of Female Employees Exposed 317,309


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an intermediate in the production of polyether polyols and as a fumigant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 51, JULY 1989
NIOSH Analytical Method, 1994: Propylene oxide, 1612
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis Studies (inhalation);some evidence:rat NTPTR* NTP-TR-267,1985
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #88


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
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GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
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JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
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SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.

Used as an intermediate in the production of polyether polyols and as a fumigant

Top 50 chemical production: 2.70 billions lbs in 1992, 2.50 billions in 1991

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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