RTECS:TY6300000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

1,2 - Propanediol, dinitrate

RTECS #: TY6300000

CAS #: 6423-43-4

UPDATE: November 2004 MW: 166.11 MF: C₃H₆N₂O₆

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,2 - Propylene glycol dinitrate

PGDN

Propylene dinitrate

Propylene glycol 1,2 - dinitrate

Propylene glycol dinitrate

Propylene glycol dinitrate (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 100 mg mild TXAPA9 22,128,1972

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 200 ppb/6 hour Behavioral: Headache TXAPA9 30,377,1974
inhalation
human lowest published toxic concentration: 1,500 ppb/5 minute Eye: Conjunctiva irritation TXAPA9 30,377,1974
intraperitoneal
guinea pig lethal dose (50 percent kill): 402 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 34,526,1973
intraperitoneal
mouse lethal dose (50 percent kill): 1,047 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section AIHAAP 34,526,1973
intraperitoneal
rat lethal dose (50 percent kill): 479 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section AIHAAP 34,526,1973
intravenous
monkey lowest published lethal dose: 410 mg/kg Eye: Ptosis

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting TXAPA9 22,128,1972
oral
mouse lethal dose (50 percent kill): 1,525 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: EKG changes not diagnostic of above

Blood: Methemoglobinemia- Carboxhemoglobinemia STGNBT -,94,1999
oral
rat lethal dose (50 percent kill): 250 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section AIHAAP 34,526,1973
subcutaneous
cat lowest published lethal dose: 200 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 15,175,1969
subcutaneous
mouse lethal dose (50 percent kill): 1,208 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 15,175,1969
subcutaneous
rat lethal dose (50 percent kill): 463 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia TXAPA9 15,175,1969

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
dog lowest published toxic concentration: 236 mg/m³/24 hour/90 day- continuous Blood: Pigmented or nucleated red blood cells

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes TXAPA9 22,128,1972
inhalation
guinea pig lowest published toxic concentration: 236 mg/m³/24 hour/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TXAPA9 22,128,1972
inhalation
monkey lowest published toxic concentration: 236 mg/m³/24 hour/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 22,128,1972
inhalation
rat lowest published toxic concentration: 236 mg/m³/24 hour/90 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 22,128,1972
skin
rabbit lowest published toxic dose: 73 gm/kg/3 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 34,526,1973

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.3 mg/m³), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.3 mg/m³), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (0.35 mg/m³), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.02 ppm (0.2 mg/m³), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.02 ppm (0.2 mg/m³), short term exposure limit 0.06 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.3 mg/m³), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 ppm (0.3 mg/m³), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m³, Skin, 2003
Occupational Exposure Limit - SWEDEN NGV 0.1 ppm (0.7 mg/m³), KTV 0.3 ppm (2 mg/m³), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.35 mg/m³), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (1.4 mg/m³), short term exposure limit 0.2 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm (skin)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE GLYCOL DINITRATE-air 10 hour time-weighted average 0.05 ppm (Sk) NIOSH* DHHS #92-100,1992

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
Human Data
Primary Irritant

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