The Registry of Toxic Effects of Chemical Substances

Propane, 1,2 - dibromo - 3 - chloro -

RTECS #: TX8750000

CAS #: 96-12-8

UPDATE: May 2005 MW: 236.35 MF: C3H5Br2Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (R/S) - 1,2 - Dibromo - 3 - chloropropane
  2. 1,2 - Dibrom - 3 - chlor - propan (German)
  3. 1,2 - Dibromo - 3 - chloropropane
  4. 1,2 - Dibromo - 3 - chloropropane (DOT:OSHA)
  5. 1,2 - Dibromo - 3 - chloropropane production - grade
  6. 1,2 - Dibromo - 3 - cloro - propano (Italian)
  7. 1,2 - Dibroom - 3 - chloorpropaan (Dutch)
  8. 1 - Chloro - 2,3 - dibromopropane
  9. 3 - Chloro - 1,2 - dibromopropane
  10. BBC 12
  11. DBCP
  12. Dibromchlorpropan (German)
  13. Dibromochloropropane
  14. Fumagon
  15. Fumazone
  16. Fumazone 86
  17. Fumazone 86E
  18. NCI - C00500
  19. Nemabrom
  1. Nemafume
  2. Nemagon
  3. Nemagon 20
  4. Nemagon 206
  5. Nemagon 20G
  6. Nemagon 90
  7. Nemagon soil fumigant
  8. Nemagone
  9. Nemanax
  10. Nemapaz
  11. Nemaset
  12. Nematocide
  13. Nematox
  14. Nemazon
  15. OS 1897
  16. Oxy DBCP
  17. Propane, 1 - chloro - 2,3 - dibromo -
  18. RCRA waste number U066
  19. SD 1897


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1% mild TXAPA9 3,545,1961
skin
rabbit 		10 gm severe TXAPA9 3,545,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 50 mg/L SCIEAS 236,933,1987
cytogenetic analysis hamster lung 200 µmol/L MUREAV 78,177,1980
cytogenetic analysis oral
rat 		3,650 µg/kg/5 day TXAPA9 48,A46,1979
dominant lethal test oral
rat 		50 mg/kg/5 day- continuous MUREAV 77,71,1980
DNA damage intraperitoneal
guinea pig 		40.2 mg/kg TXCYAC 58,133,1989
DNA damage intraperitoneal
mouse 		100 mg/kg MUREAV 419,13,1998
DNA damage rat testis 173 mg/L CBTOE2 1(3),181,1985
DNA damage intraperitoneal
rat 		35 mg/kg CBTOE2 1(3),181,1985
DNA damage intraperitoneal
rat 		1,182 µg/kg CRTOEC 4,528,1991
DNA damage rat liver 5 µmol/L CRNGDP 10,49,1989
DNA damage rabbit other cell types 300 µmol/L MUREAV 285,303,1993
DNA damage rabbit other cell types 30 µmol/L MUREAV 285,303,1993
DNA inhibition human HeLa cell 10 mmol/L MUREAV 92,427,1982
DNA repair Escherichia coli 20,900 µg/disc BECTA6 14,8,1975
unscheduled DNA synthesis intraperitoneal
mouse 		100 mg/kg MUREAV 68,169,1979
unscheduled DNA synthesis intraperitoneal
rat 		150 mg/kg MUREAV 203,135,1988
mutation in microorganisms Bacillus subtilis 1 nmol/plate (-enzymatic activation step) MSERDS 5,93,1981
mutation in microorganisms mouse lymphocyte 20 mg/L (+enzymatic activation step) CBTOE2 3,391,1987
mutation in microorganisms Salmonella typhimurium 10 nL/well (+enzymatic activation step) STEVA8 11,223,1979
mutation in microorganisms Salmonella typhimurium 500 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 3),15,1985
micronucleus test intraperitoneal
mouse 		50 mg/kg MUREAV 389,3,1997
micronucleus test oral
mouse 		51.4 mg/kg/2 day- intermittent GISAAA 12,41,1993
micronucleus test oral
mouse 		20.4 mg/kg/4 day- intermittent GISAAA 12,41,1993
micronucleus test oral
rat 		75 mg/kg MUREAV 234,129,1990
micronucleus test oral
rat 		12.68 mg/kg/4 day- intermittent GISAAA 12,41,1993
mutation in mammalian somatic cells mouse lymphocyte 83,700 µg/L SCIEAS 236,933,1987
morphological transform hamster embryo 7 mg/L CBTOE2 3,391,1987
other mutation test systems Escherichia coli 50 mg/L MUREAV 131,101,1984
sister chromatid exchange hamster ovary 10 mg/L SCIEAS 236,933,1987
sister chromatid exchange hamster lung 500 µmol/L MUREAV 78,177,1980
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		17,700 ppb/3 hour- continuous ENMUDM 4,681,1982
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		100 ppm/3 day HCKHDV 5(5),7,1984
specific locus test intraperitoneal
mouse 		106 mg/kg MUREAV 174,145,1986
sperm morphology oral
rat 		3,650 µg/kg/5 day TXAPA9 48,A46,1979
sperm morphology oral
rabbit 		375 mg/kg/10 week- intermittent FAATDF 6,628,1986
heritable translocation test oral
Drosophila melanogaster 		200 ppm ENMUDM 7,349,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10 ppm/6 hour (4 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 3,104,1983
inhalation
rat 		lowest published toxic concentration: 1 ppm/6 hour (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FAATDF 3,104,1983
inhalation
rabbit 		lowest published toxic concentration: 1 ppm/6 hour (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		FAATDF 2,241,1982
inhalation
rabbit 		lowest published toxic concentration: 10 ppm/6 hour (40 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FAATDF 2,241,1982
intraperitoneal
rat 		lowest published toxic dose: 20,090 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male

Reproductive: Specific developmental abnormalities: Urogenital system 		CRTOEC 4,528,1991
oral
mouse 		lowest published toxic dose: 875 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB85118644/AS
oral
mouse 		lowest published toxic dose: 100 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB85118644/AS
oral
mouse 		lowest published toxic dose: 100 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB85118644/AS
oral
rat 		lowest published toxic dose: 200 mg/kg (1 day male) Reproductive: Other effects on male TOXID9 4,135,1984
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BECTA6 21,483,1979
oral
rat 		lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		MUREAV 101,321,1982
oral
rat 		lowest published toxic dose: 50 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 77,71,1980
oral
rat 		lowest published toxic dose: 375 mg/kg (75 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		HYSAAV 36(1-3),344,1971
oral
rabbit 		lowest published toxic dose: 92,657 µg/kg (10 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FAATDF 6,638,1986
subcutaneous
rat 		lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		ANDRDQ 23,363,1991
subcutaneous
rat 		lowest published toxic dose: 33 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 71,294,1983
subcutaneous
rat 		lowest published toxic dose: 19 mg/kg (19 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		TXAPA9 90,299,1987
subcutaneous
rat 		lowest published toxic dose: 40 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 79,54,1985
subcutaneous
rat 		lowest published toxic dose: 1 mg/kg (24 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) BIREBV 31,454,1984
unreported route
rat 		lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GISAAA 40(6),101,1975
unreported route
rat 		lowest published toxic dose: 150 mg/kg (14-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		HBPTO* 1,737,2001
unreported route
rat 		lowest published toxic dose: 150 mg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		HBPTO* 1,737,2001
unreported route
rat 		lowest published toxic dose: 150 mg/kg (18-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		HBPTO* 1,737,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		JCROD7 98,75,1980
inhalation
mouse 		toxic concentration (other than lowest) : 3 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		JCROD7 98,75,1980
inhalation
mouse 		toxic concentration (other than lowest) : 600 ppb/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		EVHPAZ 47,365,1983
inhalation
mouse 		toxic concentration (other than lowest) : 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		NTPTR* NTP-TR-206,1982
inhalation
mouse 		toxic concentration (other than lowest) : 3 ppm/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		NTPTR* NTP-TR-206,1982
inhalation
mouse 		lowest published toxic concentration: 136.8 mg/kg/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NTIS** PB82-225632
inhalation
mouse 		lowest published toxic concentration: 37.08 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTIS** PB82-225632
inhalation
rat 		lowest published toxic concentration: 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		BJCAAI 42,772,1980
inhalation
rat 		toxic concentration (other than lowest) : 600 ppb/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors 		EVHPAZ 47,365,1983
inhalation
rat 		toxic concentration (other than lowest) : 3 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		BJCAAI 42,772,1980
inhalation
rat 		toxic concentration (other than lowest) : 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors 		NTPTR* NTP-TR-206,1982
inhalation
rat 		toxic concentration (other than lowest) : 3 ppm/6 hour/84 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors 		NTPTR* NTP-TR-206,1982
inhalation
rat 		lowest published toxic concentration: 18.54 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		NTIS** PB82-225632
inhalation
rat 		lowest published toxic concentration: 15.45 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors 		NTIS** PB82-225632
oral
mouse 		lowest published toxic dose: 49 gm/kg/47 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NCITR* NCI-TR-28,1978
oral
rat 		lowest published toxic dose: 5,475 mg/kg/73 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NCITR* NCI-TR-28,1978
oral
rat 		toxic dose : 9,280 mg/kg/64 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		NCITR* NCI-TR-28,1978
subcutaneous
rat 		lowest published toxic dose: 240 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		TOLED5 31(Suppl),202,1986
subcutaneous
rat 		toxic dose : 240 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		TOLED5 31(Suppl),202,1986
skin
mouse 		lowest published toxic dose: 100 gm/kg/74 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JJIND8 63,1433,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 103 ppm/8 hour N/R FEPRA7 15,448,1956
inhalation
rat 		lethal concentration (50 percent kill): 98 mg/m3/4 hour N/R VCVGH* -,654,1990
intraperitoneal
guinea pig 		lowest published lethal dose: 40 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
hamster 		lowest published lethal dose: 161 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
mouse 		lethal dose (50 percent kill): 123 mg/kg N/R MUREAV 68,169,1979
intraperitoneal
mouse 		lowest published toxic dose: 80.4 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
mouse 		lowest published lethal dose: 120 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
rat 		lowest published toxic dose: 40.2 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
rat 		lowest published lethal dose: 80.4 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		CHIRA* 7,359,1995
oral
chicken 		lethal dose (50 percent kill): 60 mg/kg N/R VCVGH* -,654,1990
oral
guinea pig 		lethal dose (50 percent kill): 150 mg/kg N/R PCOC** -,797,1966
oral
mouse 		lethal dose (50 percent kill): 257 mg/kg N/R GUCHAZ 6,172,1973
oral
rat 		lethal dose (50 percent kill): 170 mg/kg N/R TXAPA9 3,545,1961
oral
rat 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Recordings from specific areas of CNS VCVGH* -,654,1990
oral
rabbit 		lethal dose (50 percent kill): 180 mg/kg N/R VCVGH* -,654,1990
subcutaneous
rat 		lethal dose (50 percent kill): 100 mg/kg N/R TXCYAC 27,287,1983
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TXAPA9 59,84,1981
subcutaneous
rat 		lowest published toxic dose: 250 mg/kg Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 1,881,2001
skin
rabbit 		lethal dose (50 percent kill): 1,400 mg/kg N/R TXAPA9 3,545,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic dose: 12 ppm/7 hour/70 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 3,545,1961
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-206,1982
inhalation
rat 		lowest published toxic dose: 10 ppm/7 hour/70 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TXAPA9 3,545,1961
inhalation
rat 		lowest published toxic concentration: 25 ppm/6 hour/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above 		NTPTR* NTP-TR-206,1982
inhalation
rat 		lowest published toxic concentration: 10 ppm/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		INHEAO 20,315,1982
inhalation
rat 		lowest published toxic dose: 12 ppm/7 hour/70 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 3,545,1961
intraperitoneal
rat 		lowest published toxic dose: 160 mg/kg/2 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Other changes 		TOLED5 8,317,1981
oral
mouse 		lowest published toxic dose: 11,940 mg/kg/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NCITR* NCI-TR-28,1978
oral
rat 		lowest published toxic dose: 3,150 mg/kg/45 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Blood: Changes in spleen 		MZUZA8 1(1),64,1970
oral
rat 		lowest published toxic dose: 2,025 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 3,545,1961
oral
rat 		lowest published toxic dose: 602 mg/kg/64 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		FAATDF 13,804,1989
parenteral
rat 		lowest published toxic dose: 350 mg/kg/4 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		REPTED 17,263,2003
parenteral
rat 		lowest published toxic dose: 350 mg/kg/4 day- intermittent Endocrine: Change in LH

Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		REPTED 17,263,2003
parenteral
rat 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 17,263,2003
subcutaneous
rat 		lowest published toxic dose: 2,400 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight 		INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 175 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BIREBV 31,454,1984
subcutaneous
rat 		lowest published toxic dose: 912.5 mg/kg/26 week- intermittent Endocrine: Change in LH

Related to Chronic Data: Changes in testicular weight 		BIREBV 31,454,1984
subcutaneous
rat 		lowest published toxic dose: 4,562 mg/kg/26 week- intermittent Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in prostate weight 		BIREBV 31,454,1984
subcutaneous
rat 		lowest published toxic dose: 912.5 mg/kg/26 week- intermittent Related to Chronic Data: Changes in testicular weight BIREBV 31,454,1984
subcutaneous
rat 		lowest published toxic dose: 182.5 mg/kg/26 week- intermittent Endocrine: Androgenic BIREBV 31,454,1984
subcutaneous
rat 		lowest published toxic dose: 240 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 540 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 1,920 mg/kg/32 week- intermittent Tumorigenic: Tumors at site of application INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 2,160 mg/kg/36 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 400 mg/kg/2 week- intermittent Skin and Appendages: Other: Hair INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 600 mg/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 2,400 mg/kg/12 week- intermittent Blood: Luekopenia

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Changes in testicular weight 		INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 6,000 mg/kg/30 week- intermittent Tumorigenic: Tumors at site of application INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 7,200 mg/kg/36 week- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count 		INHEAO 27,49,1989
subcutaneous
rat 		lowest published toxic dose: 350 mg/kg/4 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TOSCF2 76,418,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,83,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 15,139,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,191,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,479,1999
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
TOLED5 135,167,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1144 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1044,1987
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DIBROMO-3-CHLOROPROPANE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1044 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2705;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 6;
Total Number of Employees Exposed 176


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a soil fumigant for control of nematodes
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-206,1982
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHIRA* Chirality. (New York Ny Wiley-Liss) V.1- 1989-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HCKHDV Huanjing Kexue. Environmental Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1976- Adopted vol. no. with Vol. 1, 1980.
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a soil fumigant for control of nematodes

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 105567-86-0
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