The Registry of Toxic Effects of Chemical Substances

1,3 - Propanediamine, N,N - dimethyl -

RTECS #: TX7525000

CAS #: 109-55-7

UPDATE: July 2000 MW: 102.21 MF: C5H14N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 3 - dimethylaminopropane
  2. N,N - Dimethyl - N - (3 - aminopropyl) amine
  3. 3 - (Dimethylamino) propylamine
  4. N,N - Dimethyl - 1,3 - diaminopropane
  1. N,N - Dimethyl - 1,3 - propanediamine
  2. N,N - Dimethyl - 1,3 - propylenediamine
  3. Propylamine, 3 - (N,N - dimethylamino) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg moderate UCDS** 12/15/1971
skin
rabbit 		100 µg/24 hour open irritation test moderate AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 1,870 mg/kg N/R AIHAAP 23,95,1962
skin
rabbit 		lethal dose (50 percent kill): 600 µL/kg N/R UCDS** 12/15/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7 gm/kg/28 day- continuous Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		NTIS** OTS0559253


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83852;
Number of Industries 5;
Total Number of Facilities 126;
Number of Occupations 11;
Total Number of Employees Exposed 998
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83852;
Number of Industries 3;
Total Number of Facilities 124;
Number of Occupations 7;
Total Number of Employees Exposed 6,127;
Total Number of Female Employees Exposed 119


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of petroleum and polymer additives, water-treating agents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as intermediate in production of petroleum and polymer additives, water-treating agents

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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