The Registry of Toxic Effects of Chemical Substances

1,2 - Propanediamine

RTECS #: TX6650000

CAS #: 78-90-0

UPDATE: September 1997 MW: 74.15 MF: C3H10N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,2 - Diaminopropane
  2. 2,3 - Diaminopropane
  1. Propylenediamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		87 mg severe UCDS** 3/12/1969
eye
rabbit 		750 µg/24 hour severe 85JCAE -,441,1986
skin
rabbit 		10 mg/24 hour open irritation test severe AMIHBC 10,61,1954
skin
rabbit 		435 mg open irritation test severe UCDS** 3/12/1969
skin
rabbit 		5 mg/24 hour severe 85JCAE -,441,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 593 mg/kg N/R YKKZAJ 97,1117,1977
oral
rat 		lethal dose (50 percent kill): 2,230 mg/kg N/R UCDS** 3/12/1969
subcutaneous
rat 		lowest published lethal dose: 909 mg/kg N/R ZEPTAT 17,59,1915
skin
rabbit 		lethal dose (50 percent kill): 500 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83465;
Number of Industries 7;
Total Number of Facilities 118;
Number of Occupations 13;
Total Number of Employees Exposed 2,614
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83465;
Number of Industries 3;
Total Number of Facilities 122;
Number of Occupations 8;
Total Number of Employees Exposed 8,346;
Total Number of Female Employees Exposed 3,070


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin, Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.

Used as intermediate in production of petroleum and polymer additives and surfactants

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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