The Registry of Toxic Effects of Chemical Substances
Propane, 1 - chloro - 1 - nitro - |
UPDATE: November 2004 | MW: 123.55 | MF: C3H6ClNO2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Salmonella typhimurium | 333 痢/plate (+/-enzymatic activation step) | EMMUEG 19(Suppl 21),2,1992 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation guinea pig | lowest published lethal concentration: 18 gm/m3/2 hour |
Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | JIHTAB 27,95,1945 |
inhalation mouse | lethal concentration (50 percent kill): 66 gm/m3/3 hour |
Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
inhalation rabbit | lowest published lethal concentration: 2 gm/m3/6 hour |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes | JIHTAB 27,95,1945 |
oral mouse | lethal dose (50 percent kill): 510 mg/kg |
Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
oral rat | lowest published lethal dose: 50 mg/kg | N/R | 85JCAE -,596,1986 |
oral rabbit | lowest published lethal dose: 50 mg/kg |
Vascular: Other changes Lung, Thorax, or Respiration: Other changes | JIHTAB 27,95,1945 |
subcutaneous mouse | lethal dose (50 percent kill): 165 mg/kg |
Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) | HYSAAV 34(10-12),429,1969 |
skin mouse | lethal dose : >5,000 mL/kg | N/R | HYSAAV 34,429,1969 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 2 ppm | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 20 ppm (100 mg/m3) | DTLVS* 3,53,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 20 ppm (100 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 20 ppm (100 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 2 ppm (10 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 20 ppm (100 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 2 ppm (10 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 2 ppm (10 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 20 ppm (100 mg/m3), short term exposure limit 30 ppm (150 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 2 ppm (10 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 20 ppm (100 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 20 ppm (100 mg/m3), JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 50 mg/m3, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 2 ppm (10 mg/m3), JAN1999 | |
Occupational Exposure Limit - TURKEY | time-weighted average 20 ppm (100 mg/m3), JAN1993 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 2 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-CHLORO-1-NITROPROPANE-air | 10 hour time-weighted average 2 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 18590; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 721 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
N/R |
REFERENCES: | |
CODEN |
REFERENCE |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
HYSAAV | Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. |
JIHTAB | Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |