The Registry of Toxic Effects of Chemical Substances

Propane, 1 - chloro - 1 - nitro -

RTECS #: TX5075000

CAS #: 600-25-9

UPDATE: November 2004 MW: 123.55 MF: C3H6ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Chloro - 1 - nitropropane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+/-enzymatic activation step) EMMUEG 19(Suppl 21),2,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 18 gm/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		JIHTAB 27,95,1945
inhalation
mouse 		lethal concentration (50 percent kill): 66 gm/m3/3 hour Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity) 		HYSAAV 34(10-12),429,1969
inhalation
rabbit 		lowest published lethal concentration: 2 gm/m3/6 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		JIHTAB 27,95,1945
oral
mouse 		lethal dose (50 percent kill): 510 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity) 		HYSAAV 34(10-12),429,1969
oral
rat 		lowest published lethal dose: 50 mg/kg N/R 85JCAE -,596,1986
oral
rabbit 		lowest published lethal dose: 50 mg/kg Vascular: Other changes

Lung, Thorax, or Respiration: Other changes 		JIHTAB 27,95,1945
subcutaneous
mouse 		lethal dose (50 percent kill): 165 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity) 		HYSAAV 34(10-12),429,1969
skin
mouse 		lethal dose : >5,000 mL/kg N/R HYSAAV 34,429,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 20 ppm (100 mg/m3) DTLVS* 3,53,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 20 ppm (100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 20 ppm (100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 20 ppm (100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 20 ppm (100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 20 ppm (100 mg/m3), short term exposure limit 30 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 20 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 20 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-CHLORO-1-NITROPROPANE-air 10 hour time-weighted average 2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18590;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 721


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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