RTECS:TX4110000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Propane, 1 - bromo -

RTECS #: TX4110000

CAS #: 106-94-5

UPDATE: November 2004 MW: 123.01 MF: C₃H₇Br

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1 - Bromopropane

Propyl bromide

n - Propyl bromide

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 821 ppm/8 hour (12 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) SAIGBL 40,414,1998
inhalation
rat lowest published toxic concentration: 200 ppm/8 hour (12 week male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands TOSCF2 54,416,2000
oral
rat lowest published toxic dose: 2 gm/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) MUREAV 101,321,1982

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lethal concentration (50 percent kill): 7,100 mg/m³ N/R VCVGH* -,593,1990
inhalation
rat lethal concentration (50 percent kill): 253 gm/m³/30 minute N/R FAVUAI 7,35,1975
inhalation
rat lethal concentration (50 percent kill): 19,700 mg/m³ N/R VCVGH* -,593,1990
inhalation
rat lowest published toxic concentration: 700 ppm/6 hour Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) TOLED5 134,237,2002
intraperitoneal
mouse lethal dose (50 percent kill): 1,210 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat lethal dose (50 percent kill): 2,950 mg/kg N/R 85GMAT -,102,1982
oral
mouse lethal dose (50 percent kill): 4,700 mg/kg N/R VCVGH* -,593,1990
oral
rat lowest published lethal dose: 4 gm/kg N/R MUREAV 101,321,1982
oral
rat lethal dose (50 percent kill): 3,600 mg/kg N/R VCVGH* -,593,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 98,408 mg/m³/30 minute/1 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage JPETAB 80,139,1944
inhalation
rat lowest published toxic concentration: 1,800 ppm/6 hour/8 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain SAIGBL 41,A42,1999
inhalation
rat lowest published toxic concentration: 400 ppm/8 hour/12 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath TOXID9 54,394,2000
inhalation
rat lowest published toxic concentration: 200 ppm/8 hour/12 week- intermittent Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes NRTXDN 24,199,2003
inhalation
rat lowest published toxic concentration: 400 ppm/8 hour/12 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NRTXDN 24,199,2003
inhalation
rat lowest published toxic concentration: 800 ppm/8 hour/12 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins NRTXDN 24,199,2003
inhalation
rat lowest published toxic concentration: 800 ppm/3 week- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 71,96,2003
inhalation
rat lowest published toxic concentration: 200 ppm/12 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Oogenesis TOSCF2 71,96,2003
inhalation
rat lowest published toxic concentration: 700 ppm/6 hour/8 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects LIFSAK 72,521,2002
inhalation
rat lowest published toxic concentration: 1,500 ppm/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 134,237,2002
inhalation
rat lowest published toxic concentration: 700 ppm/8 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 134,237,2002
inhalation
rat lowest published toxic concentration: 1,500 ppm/4 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOLED5 134,237,2002
inhalation
rat lowest published toxic concentration: 700 ppm/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOLED5 134,237,2002
inhalation
rat lowest published toxic concentration: 1,500 ppm/3 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOLED5 134,237,2002
intraperitoneal
mouse lowest published toxic dose: 1,350 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes SAIGBL 40,415,1998
oral
rat lowest published toxic dose: 560 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,26,2003
oral
rat lowest published toxic dose: 1,960 mg/kg/7 week- continuous Reproductive: Maternal effects: Menstrual cycle changes or disorders TOXID9 72,26,2003
oral
rat lowest published toxic dose: 1,680 mg/kg/12 week- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders TOXID9 72,26,2003
unreported route
rat lowest published toxic dose: 37,887 mg/kg/4 week- intermittent Autonomic Nervous System: Ganglion blocker

Behavioral: Somnolence (general depressed activity) SAIGBL 41,A1,1999

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000

REFERENCES:
CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
Tumorigen
Reproductive Effector

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