The Registry of Toxic Effects of Chemical Substances

Potassium sulfate (2:1)

RTECS #: TT5900000

CAS #: 7778-80-5

UPDATE: July 2002 MW: 174.26 MF: O4S•2K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Sulfuric acid, dipotassium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 60 mg/m3 Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		VCVN1* -,48,1998
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 1,250 mg/kg N/R VCVN1* -,48,1998
intraperitoneal
guinea pig 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R VCVN1* -,48,1998
intraperitoneal
mouse 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
intraperitoneal
rat 		lethal dose (50 percent kill): 1,250 mg/kg N/R VCVN1* -,48,1998
intraperitoneal
rat 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
oral
guinea pig 		lethal dose (50 percent kill): 6,600 mg/kg N/R VCVN1* -,48,1998
oral
guinea pig 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
oral
mouse 		lethal dose (50 percent kill): 6,600 mg/kg N/R VCVN1* -,48,1998
oral
mouse 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
oral
rat 		lethal dose (50 percent kill): 6,600 mg/kg N/R VCVN1* -,48,1998
oral
rat 		lowest published lethal dose: 3,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression 		VCVN1* -,48,1998
oral
woman 		lowest published lethal dose: 750 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea 		AEXPBL 21,169,1886
subcutaneous
guinea pig 		lowest published lethal dose: 3 gm/kg N/R HBAMAK 4,1360,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 15 mg/m3/4 hour/17 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Changes in: Na

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GTPZAB 28(7),47,1984
inhalation
rat 		lowest published toxic concentration: 15 mg/m3/4 hour/16 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Immunological Including Allergic: Decreased immune response 		VCVN1* -,48,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60540;
Number of Industries 23;
Total Number of Facilities 2,504;
Number of Occupations 40;
Total Number of Employees Exposed 24,082
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1826;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 1;
Total Number of Employees Exposed 238
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60540;
Number of Industries 62;
Total Number of Facilities 6,540;
Number of Occupations 76;
Total Number of Employees Exposed 120,743;
Total Number of Female Employees Exposed 31,373


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a filler in the manufacture of resinoid grinding wheels
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a filler in the manufacture of resinoid grinding wheels

RTECS Compound Description:
   Human Data

ALT CAS #: 10233-01-9
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