The Registry of Toxic Effects of Chemical Substances

Potassium nitrate

RTECS #: TT3700000

CAS #: 7757-79-1

UPDATE: August 2003 MW: 179.31 MF: KNO3•K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Collo - Bo
  2. Kaliumnitrat (German)
  3. Niter
  4. Nitre
  1. Nitric acid, potassium salt
  2. Saltpeter
  3. Vicknite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Escherichia coli 5 pph JGMIAN 8,45,1953


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 15 gm/kg (24 week prior to copulation) Reproductive: Effects on newborn: Stillbirth TXAPA9 12,179,1968
oral
guinea pig 		lowest published toxic dose: 1,670 gm/kg (29 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Other effects to embryo or fetus 		TXAPA9 12,179,1968
oral
rat 		lowest published toxic dose: 22 gm/kg (1-22 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JANSAG 15,1291,1956
oral
rat 		lowest published toxic dose: 598 mg/kg (1-22 day pregnant/5 day after birth) Reproductive: Effects on newborn: Behavioral APHHDU 74,69,1989
oral
rabbit 		lowest published toxic dose: 6,505 mg/kg (23-27 day pregnant) Reproductive: Effects on fertility: Abortion SOVEA7 27,246,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
cat 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
rat 		lethal dose (50 percent kill): 3,750 mg/kg N/R NYKZAU 81,469,1983
oral
rat 		lethal dose (50 percent kill): 3,540 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVN5* -,49,1993
oral
rat 		lowest published toxic dose: 10 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN5* -,49,1993
oral
rabbit 		lethal dose (50 percent kill): 1,901 mg/kg N/R SOVEA7 27,246,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 36 gm/kg/90 day- intermittent Gastrointestinal: Other changes BECTA6 60,185,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,318,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80350;
Number of Industries 67;
Total Number of Facilities 4,730;
Number of Occupations 53;
Total Number of Employees Exposed 36,204
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80350;
Number of Industries 67;
Total Number of Facilities 4,503;
Number of Occupations 65;
Total Number of Employees Exposed 66,562;
Total Number of Female Employees Exposed 26,088


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fireworks, fluxes, glass manufacture, matches, gunpowders, and as a diuretic
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8804
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
APHHDU Acta Physiologica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) V.61- 1983-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SOVEA7 Southwestern Veterinarian. (College of Veterinary Medicine, Texas A & M Univ., College Station, TX 77843) V.1- 1948-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in fireworks, fluxes, glass manufacture, matches, gunpowders, and as a diuretic

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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