The Registry of Toxic Effects of Chemical Substances

Potassium chloride

RTECS #: TS8050000

CAS #: 7447-40-7

UPDATE: February 2005 MW: 74.55 MF: ClK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chlorid draselny (Czech)
  2. Chloropotassuril
  3. Dipotassium dichloride
  4. Emplets potassium chloride
  5. Enseal
  6. K - Dur
  7. K - Lor
  8. K - Lyte/Cl
  9. K - Predne - dome
  10. Kalitabs
  11. Kaochlor
  12. Kaon - Cl
  13. Kaon - Cl 10
  14. Kaon - Cl TABS
  1. Kay ciel
  2. Klor - Con
  3. Klotrix
  4. Monopotassium chloride
  5. Muriate of potash
  6. Pfiklor
  7. Potassium monochloride
  8. Potavescent
  9. Rekawan
  10. Slow K
  11. Super K
  12. Super K (salt)
  13. Tripotassium trichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,8,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 12 gm/L FCTOD7 22,501,1984
cytogenetic analysis hamster ovary 140 mmol/L MUREAV 189,15,1987
DNA damage hamster ovary 260 mmol/L MUREAV 189,15,1987
unscheduled DNA synthesis oral
rat 		1,500 µg/kg JJCREP 80,424,1989
mutation in microorganisms mouse lymphocyte 2,048 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),37,1988
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+/-enzymatic activation step) NTPTB* APR1982
mutation in microorganisms Saccharomyes cerevisiae 2,500 mmol/L (-enzymatic activation step) GENRA8 37,173,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 400 mmol/L MUTAEX 1,21,1986
sister chromatid exchange hamster ovary 180 mmol/L MUREAV 189,15,1987
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 300 mmol/L MUTAEX 1,21,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
guinea pig 		lowest published lethal dose: 130 mg/kg N/R AEPPAE 131,171,1928
intraperitoneal
guinea pig 		lowest published lethal dose: 900 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes 		JPETAB 35,1,1929
intraperitoneal
mouse 		lethal dose (50 percent kill): 620 mg/kg N/R COREAF 256,1043,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 660 mg/kg N/R FCTXAV 3,597,1965
intravenous
guinea pig 		lowest published lethal dose: 77 mg/kg N/R AEPPAE 131,171,1928
intravenous
mouse 		lethal dose (50 percent kill): 117 mg/kg N/R EJTXAZ 8,188,1975
intravenous
rat 		lethal dose (50 percent kill): 142 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		ARZNAD 14,1128,1964
oral
guinea pig 		lowest published lethal dose: 2,500 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes 		JPETAB 35,1,1929
oral
infant 		lowest published lethal dose: 938 mg/kg/2 day Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Changes in: K 		JAMAAP 240,1339,1978
oral
man 		lowest published lethal dose: 20 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting

Blood: Change in clotting factors 		LANCAO 2,919,1980
oral
man 		lowest published toxic dose: 214.29 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		JTCTDW 39,641,2001
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R IYKEDH 21,257,1990
oral
rat 		lethal dose (50 percent kill): 2,600 mg/kg N/R 28ZPAK -,8,1972
oral
woman 		lowest published toxic dose: 60 mg/kg/ day Gastrointestinal: Nausea or vomiting

Blood: Change in clotting factors 		LANCAO 2,919,1980
parenteral
guinea pig 		lowest published lethal dose: 40 mg/kg N/R AEPPAE 131,171,1928
subcutaneous
frog 		lowest published lethal dose: 2,120 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
guinea pig 		lowest published lethal dose: 2,550 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
pigeon 		lowest published lethal dose: 2,210 mg/kg N/R HBAMAK 4,1289,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 75.6 gm/kg/6 week- continuous Kidney, Ureter, and Bladder: Urine volume increased FCTOD7 42,135,2004
oral
rat 		lowest published toxic dose: 983 gm/kg/78 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FCTOD7 42,135,2004
oral
rat 		lowest published toxic dose: 1,536 gm/kg/130 week- continuous Endocrine: Adrenal cortex hyperplasia FCTOD7 42,135,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
INTEAG 15,7,1974
TOXICOLOGY REVIEW
MUREAV 5601012004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60360;
Number of Industries 97;
Total Number of Facilities 14,471;
Number of Occupations 88;
Total Number of Employees Exposed 122,749
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60360;
Number of Industries 147;
Total Number of Facilities 16,061;
Number of Occupations 125;
Total Number of Employees Exposed 387,624;
Total Number of Female Employees Exposed 175,287


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as fertilizer, in food and pharmaceuticals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1960-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)

Used as fertilizer, in food and pharmaceuticals

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 12599-00-7
ALT CAS #: 59217-68-4
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