The Registry of Toxic Effects of Chemical Substances

Polychlorinated biphenyl (aroclor 1254)

RTECS #: TQ1360000

CAS #: 11097-69-1

UPDATE: May 2005 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Arochlor 1254
  2. Aroclor 1254
  3. Chlorierte biphenyle, chlorgehalt 54% (German)
  4. Chlorodiphenyl (54% Cl)
  5. Chlorodiphenyl (54% chlorine)
  1. Chlorodiphenyl (54% chlorine) (ACGIH,OSHA)
  2. Clorodifenili, cloro 54% (Italian)
  3. Diphenyle chlore, 54% de chlore (French)
  4. NCI - C02664
  5. PCB (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis chicken embryo 1 mg/L/48 hour REPTED 19,79,2004
cytogenetic analysis intraperitoneal
other fish 		50 mg/kg CBPCEE 82,489,1985
DNA adduct human liver 60 µmol/L/24 hour TXAPA9 188,81,2003
DNA damage oral
rat 		1,295 mg/kg BSIBAC 57,407,1981
DNA damage intraperitoneal
rat 		500 mg/kg BSIBAC 57,407,1981
DNA damage rat liver 300 µmol/L SinJF# 26OCT1982
unscheduled DNA synthesis rat liver 20 mg/L CNREA8 42,3010,1982
micronucleus test intraperitoneal
other fish 		50 mg/kg CYTBAI 47,147,1986
morphological transform mouse fibroblast 5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform oral
rat 		25 ppm/2 year- continuous EVHPAZ 60,89,1985
sperm morphology oral
other insects 		808 mg CYTBAI 11,167,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 250 mg/kg (15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic 		IJBOBV 25,1209,1993
oral
mammal (species unspecified) 		lowest published toxic dose: 14 mg/kg (30 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) TOXID9 4,83,1984
oral
mouse 		lowest published toxic dose: 59,400 µg/kg (3 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral NTOTDY 3,5,1981
oral
mouse 		lowest published toxic dose: 222 mg/kg (6-21 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		NRTXDN 23,375,2002
oral
mouse 		lowest published toxic dose: 252 mg/kg (1-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects 		NRTXDN 23,375,2002
oral
rat 		lowest published toxic dose: 192 mg/kg (6 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		ENVRAL 31,76,1983
oral
rat 		lowest published toxic dose: 148 mg/kg (6-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral FAATDF 33,120,1996
oral
rat 		lowest published toxic dose: 35 mg/kg (10-16 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 139,252,1996
oral
rat 		lowest published toxic dose: 90 mg/kg (7-15 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system FCTXAV 11,471,1973
oral
rat 		lowest published toxic dose: 40 mg/kg (5 day after birth) Reproductive: Effects on newborn: Delayed effects BECTA6 38,946,1987
oral
rat 		lowest published toxic dose: 750 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FCTXAV 13,507,1975
oral
rat 		lowest published toxic dose: 96 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Behavioral BRREAP 850,87,1999
oral
rat 		lowest published toxic dose: 304 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects HERED3 144,196,2000
oral
rat 		lowest published toxic dose: 380 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 15,243,1995
oral
rat 		lowest published toxic dose: 38 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system 		TOXID9 15,157,1995
oral
rat 		lowest published toxic dose: 152 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOXID9 15,157,1995
oral
rat 		lowest published toxic dose: 38 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Eye, ear TOXID9 30,25,1996
oral
rat 		lowest published toxic dose: 35 mg/kg (10-16 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TXAPA9 136,269,1996
oral
rat 		lowest published toxic dose: 320 µg/kg (5 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		ENVRAL 66,52,1994
oral
rat 		lowest published toxic dose: 160 µg/kg (5 day after birth) Reproductive: Effects on newborn: Physical ENVRAL 66,52,1994
oral
rat 		lowest published toxic dose: 222 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 174,188,2001
oral
rat 		lowest published toxic dose: 462.5 mg/kg (1 day pregnant-15 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		BECTA6 48,715,1992
oral
rat 		lowest published toxic dose: 4 gm/kg (12-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 21,62A,1980
oral
rat 		lowest published toxic dose: 396 mg/kg (28 day prior to copulation-16 day after birth) Reproductive: Specific developmental abnormalities: Gastrointestinal system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOSCF2 77,315,2004
oral
rat 		lowest published toxic dose: 228 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Effects on newborn: Delayed effects 		TOSCF2 68,458,2002
oral
rat 		lowest published toxic dose: 675 mg/kg (1-22 day pregnant/23 day after birth) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOSCF2 77,51,2004
oral
rabbit 		lowest published toxic dose: 350 mg/kg (1-28 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death 		EVPHBI 1,67,1971
oral
rabbit 		lowest published toxic dose: 280 mg/kg (1-28 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BECTA6 6,120,1971
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg (14 day prior to copulation) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		AECTCV 44,72,2003
subcutaneous
rat 		lowest published toxic dose: 90 mg/kg (10-18 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system 		TOLED5 135,S83,2001
subcutaneous
rat 		lowest published toxic dose: 270 mg/kg (10-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,133,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 500 mg/kg (19 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors 		JJIND8 71,157,1983
oral
mouse 		lowest published toxic dose: 17 gm/kg/48 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		JNCIAM 53,547,1974
oral
rat 		lowest published toxic dose: 73,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 60,89,1985
oral
rat 		toxic dose : 1 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		CNREA8 41,5052,1981
oral
rat 		toxic dose : 3 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		CNREA8 41,5052,1981
oral
rat 		toxic dose : 4 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors 		NCITR* NCI-TR-38,1978
skin
mouse 		lowest published toxic dose: 4 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		BECTA6 18,552,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): >1,250 mg/kg N/R AECTCV 6,279,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 880 mg/kg N/R BECTA6 8,245,1972
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Liver: Changes in liver weight

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		ENVPAF 72,57,1991
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg Liver: Other changes

Blood: Other changes 		ENVPAF 72,57,1991
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Blood: Other changes ENVPAF 72,57,1991
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		ENVPAF 72,57,1991
intraperitoneal
mouse 		lowest published toxic dose: 500 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 71,254,1983
intraperitoneal
non-mammalian species 		lowest published toxic dose: 20 mg/kg Liver: Liver function tests impaired

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOLED5 136,97,2002
intraperitoneal
non-mammalian species 		lowest published toxic dose: 70 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 136,97,2002
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) MOPMA3 13,924,1977
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Endocrine: Evidence of thyroid hypofunction ARTODN Suppl.13,440,1989
intravenous
chicken 		lowest published toxic dose: 300 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Effect on mitochondrial function 		JBCHA3 255,8275,1980
intravenous
rat 		lethal dose (50 percent kill): 358 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		FCTXAV 12,63,1974
intravenous
rat 		lethal dose (50 percent kill): 358 mg/kg N/R VCVGK* -,58,1984
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 4 gm/kg N/R AECTCV 6,279,1977
oral
rat 		lethal dose (50 percent kill): 1,010 mg/kg N/R TXAPA9 60,33,1981
oral
rat 		lowest published toxic dose: 300 mg/kg Liver: Other changes

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		EVHPAZ 109,1163,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
domestic animal 		lowest published toxic dose: 5 mg/kg/20 day- intermittent Liver: Other changes JEPOEC 12,17,1993
intramuscular
domestic animal 		lowest published toxic dose: 7,500 µg/kg/12 week- intermittent Liver: Other changes JEPOEC 12,17,1993
intramuscular
rabbit 		lowest published toxic dose: 25 mg/kg/20 day- intermittent Liver: Other changes JEPOEC 12,17,1993
intraperitoneal
wild bird 		lowest published toxic dose: 320 mg/kg/13 day- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other 		CBCPAI 99C,251,1991
intraperitoneal
guinea pig 		lowest published toxic dose: 320 mg/kg/13 day- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other 		CBCPAI 99C,251,1991
intraperitoneal
non-mammalian species 		lowest published toxic dose: 320 mg/kg/13 day- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Other 		CBCPAI 99C,251,1991
intraperitoneal
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		JTEHD6 4,107,1978
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg/2 week- intermittent Biochemical: Metabolism (intermediary): Other BECTA6 19,729,1978
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		REPTED 19,201,2004
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		REPTED 19,201,2004
oral
domestic bird 		lowest published toxic dose: 431 mg/kg/8 week- continuous Autonomic Nervous System: Sympathomimetic

Liver: Changes in liver weight

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TXAPA9 53,75,1980
oral
wild bird 		lowest published toxic dose: 2,800 mg/kg/8 week- intermittent Endocrine: Changes in thyroid weight BECTA6 8,306,1972
oral
mammal (species unspecified) 		lowest published toxic dose: 119 mg/kg/28 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 15,393,1986
oral
mammal (species unspecified) 		lowest published toxic dose: 180 mg/kg/17 week- continuous Cardiac: Changes in heart weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AECTCV 6,279,1977
oral
monkey 		lowest published toxic dose: 8,365 µg/kg/4.5 year- intermittent Immunological Including Allergic: Decrease in humoral immune response FAATDF 16,773,1991
oral
monkey 		lowest published toxic dose: 170 mg/kg/2.3 year- intermittent Eye: Other eye effects

Blood: Changes in spleen

Skin and Appendages: Other: Nails 		TOPADD 14,1,1986
oral
monkey 		lowest published toxic dose: 14.6 mg/kg/2 year- intermittent Endocrine: Other changes AECTCV 19,939,1990
oral
monkey 		lowest published toxic dose: 58.4 mg/kg/2 year- intermittent Endocrine: Effect on menstrual cycle AECTCV 19,939,1990
oral
mouse 		lowest published toxic dose: 672 mg/kg/28 day- continuous Liver: Changes in liver weight JTEHD6 5,605,1979
oral
mouse 		lowest published toxic dose: 90 mg/kg/15 day- continuous Behavioral: Altered sleep time (including change in righting reflex)

Liver: Changes in liver weight

Endocrine: Changes in adrenal weight 		TXAPA9 40,91,1977
oral
mouse 		lowest published toxic dose: 178 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain BECTA6 12,394,1974
oral
mouse 		lowest published toxic dose: 552 mg/kg/14 day- continuous Behavioral: Altered sleep time (including change in righting reflex)

Liver: Changes in liver weight 		BECTA6 12,394,1974
oral
mouse 		lowest published toxic dose: 1,965 mg/kg/14 day- continuous Endocrine: Changes in adrenal weight BECTA6 12,394,1974
oral
mouse 		lowest published toxic dose: 3,360 mg/kg/7 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 12,394,1974
oral
mouse 		lowest published toxic dose: 168 mg/kg/2 week- continuous Behavioral: Altered sleep time (including change in righting reflex)

Liver: Changes in liver weight 		ENPBBC 5,308,1975
oral
mouse 		lowest published toxic dose: 672 mg/kg/2 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		ENPBBC 5,308,1975
oral
mouse 		lowest published toxic dose: 75.6 mg/kg/21 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TXAPA9 188,6,2003
oral
non-mammalian species 		lowest published toxic dose: 102.9 mg/kg/30 day- continuous Endocrine: Androgenic

Endocrine: Estrogenic

Related to Chronic Data: Changes in ovarian weight 		MAERE* 24,179,1988
oral
non-mammalian species 		lowest published toxic dose: 30 mg/kg/30 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		BIREBV 64,955,2001
oral
non-mammalian species 		lowest published toxic dose: 30 mg/kg/15 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		BIREBV 64,955,2001
oral
quail 		lowest published toxic dose: 588 mg/kg/12 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		JTEHD6 51,57,1997
oral
rat 		lowest published toxic dose: 600 mg/kg/4 week- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 40,68,1997
oral
rat 		lowest published toxic dose: 5,475 mg/kg/52 week- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		AECTCV 8,191,1979
oral
rat 		lowest published toxic dose: 1,652 mg/kg/35 week- continuous Liver: Other changes

Liver: Changes in liver weight 		AEHLAU 25,354,1972
oral
rat 		lowest published toxic dose: 210 mg/kg/20 week- continuous Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport 		TXAPA9 37,112,1976
oral
rat 		lowest published toxic dose: 105 mg/kg/15 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Musculoskeletal: Other changes 		TXCYAC 57,83,1989
oral
rat 		lowest published toxic dose: 50,400 µg/kg/12 week- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 12,669,1974
oral
rat 		lowest published toxic dose: 60 mg/kg/20 day- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JTEHD6 3,769,1977
oral
rat 		lowest published toxic dose: 70 mg/kg/1 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		BECTA6 12,145,1974
oral
rat 		lowest published toxic dose: 1,920 µg/kg/4 day- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		BECTA6 34,427,1985
oral
rat 		lowest published toxic dose: 1,820 mg/kg/52 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 1,750 mg/kg/10 week- intermittent Endocrine: Changes in pituitary weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 20,288,1993
oral
rat 		lowest published toxic dose: 2,625 mg/kg/15 week- intermittent Endocrine: Changes in pituitary weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 20,288,1993
oral
rat 		lowest published toxic dose: 35 mg/kg/5 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Evidence of thyroid hypofunction 		FAATDF 20,288,1993
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Endocrine: Effect on menstrual cycle

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		CBCPAI 77C ,65,1984
oral
rat 		lowest published toxic dose: 632.4 mg/kg/372 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 1,055.6 mg/kg/182 day- continuous Musculoskeletal: Other changes TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 309.4 mg/kg/182 day- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 750 mg/kg/5 day- intermittent Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BECTA6 13,14,1975
oral
rat 		lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 13,14,1975
oral
rat 		lowest published toxic dose: 10 mg/kg/40 day- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987
oral
rat 		lowest published toxic dose: 10 mg/kg/20 day- continuous Endocrine: Evidence of thyroid hypofunction ENDOAO 121,520,1987
oral
rat 		lowest published toxic dose: 7.5 mg/kg/150 day- continuous Biochemical: Metabolism (intermediary): Other ENDOAO 121,520,1987
oral
rat 		lowest published toxic dose: 8.4 mg/kg/4 week- continuous Endocrine: Evidence of thyroid hyperfunction VAAZA2 33,213,1980
oral
rat 		lowest published toxic dose: 84 mg/kg/4 week- continuous Endocrine: Toxic goiter- hypofunction VAAZA2 33,213,1980
oral
rat 		lowest published toxic dose: 10.5 mg/kg/5 week- continuous Endocrine: Other changes JEPTDQ 1,587,1978
oral
rat 		lowest published toxic dose: 756 mg/kg/18 week- continuous Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens 		JNCIAM 66,509,1981
oral
rat 		lowest published toxic dose: 165 mg/kg/11 day- intermittent Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other 		CJPPA3 54,23,1976
oral
rat 		lowest published toxic dose: 21 mg/kg/7 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ATSUDG 12,85,1988
oral
rat 		lowest published toxic dose: 63 mg/kg/7 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases ATSUDG 12,85,1988
oral
rat 		lowest published toxic dose: 33.6 mg/kg/28 day- continuous Liver: Fatty liver degeneration

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JTEHD6 6,421,1980
oral
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		EXMPA6 22,376,1975
oral
rat 		lowest published toxic dose: 42 mg/kg/7 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOXID9 72,313,2003
oral
rat 		lowest published toxic dose: 56 mg/kg/14 day- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 177,227,2002
oral
rat 		lowest published toxic dose: 42 mg/kg/7 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction 		TOSCF2 65,184,2002
oral
rabbit 		lowest published toxic dose: 4,200 mg/kg/14 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Changes in uterine weight 		AJPAA4 70,363,1973
oral
rabbit 		lowest published toxic dose: 5.94 mg/kg/33 day- continuous Immunological Including Allergic: Decrease in humoral immune response TXAPA9 32,587,1975
oral
rabbit 		lowest published toxic dose: 10.26 mg/kg/57 day- continuous Endocrine: Other changes TXAPA9 32,587,1975
oral
rabbit 		lowest published toxic dose: 119.7 mg/kg/57 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		TXAPA9 32,587,1975
parenteral
duck 		lowest published toxic dose: 25 mg/kg/10 week- intermittent Liver: Other changes JEPOEC 12,17,1993
subcutaneous
domestic animal 		lowest published toxic dose: 20 mg/kg/20 day- intermittent Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPOEC 9,283,1989
subcutaneous
rabbit 		lowest published toxic dose: 25 mg/kg/20 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		JEPOEC 9,283,1989
skin
rat 		lowest published toxic dose: 120 µg/kg/4 day- intermittent Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other 		CJPPA3 54,23,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 18,43,1978
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,322,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMSUDL 7,322,1987
TOXICOLOGY REVIEW
EVHPAZ 1,105,1972
TOXICOLOGY REVIEW
ARVPAX 14,139,1974
TOXICOLOGY REVIEW
RREVAH 44,1,1973
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
BISNAS 20,958,1970
TOXICOLOGY REVIEW
ENVRAL 5,249,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,52,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Skin, Carcinogen JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.5 mg/m3), Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 ppm (0.5 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, Skin, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg/m3, KTV 0.3 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIPHENYL (54% Cl)-air Carcinogen;
10 hour time-weighted average 0.001 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1181;
Number of Industries 5;
Total Number of Facilities 170;
Number of Occupations 7;
Total Number of Employees Exposed 3,702;
Total Number of Female Employees Exposed 1,725


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027)
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986
NIOSH Analytical Method, 1994: Polychlorobiphenyls, 5503; in serum, 8004
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-38,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BISNAS BioScience. (American Institute of Biological Sciences, 1401 Wilson Blvd., Arlington, VA 22209) V.14- 1964-
BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1966-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark) V.2-5, 1972-75. Discontinued.
ENVPAF Environmental Pollution. (Barking, UK) V.1-20, 1970-79.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EVPHBI Environmental Physiology. (Copenhagen, Denmark) V.1(1-4), 1971. For publisher information, see ENPBBC.
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HERED3 Hearing Research. (Elsevier Science B. V., POB 211, 1000 AE Amsterdam, Netherlands) V. 1- 1986-
IJBOBV International Journal of Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1970-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MAERE* Marine Environmental Research. (Kidlington, Oxford : Elsevier) V. 1- 1978-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

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