The Registry of Toxic Effects of Chemical Substances

Polychlorinated biphenyl (aroclor 1242)

RTECS #: TQ1356000

CAS #: 53469-21-9

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Arochlor 1242
  2. Aroclor 1242
  3. Chlorierte biphenyle, chlorgehalt 42% (German)
  4. Chlorodiphenyl (42% Cl)
  5. Chlorodiphenyl (42% chlorine)
  1. Chlorodiphenyl (42% chlorine) (ACGIH,OSHA)
  2. Clorodifenili, cloro 42% (Italian)
  3. Diphenyle chlore, 42% de chlore (French)
  4. Gechloreerdedifenyl (Dutch)
  5. PCB (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
other mutation test systems mouse other cell types 25 ppm/4 hour EESADV 3,10,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 188 mg/kg (17 week prior to copulation-28 day after birth) Reproductive: Effects on fertility: Other measures of fertility AECTCV 9,627,1980
oral
mouse 		lowest published toxic dose: 3,300 mg/kg (14 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		REPTED 15,281,2001
oral
mouse 		lowest published toxic dose: 825 mg/kg (14 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 15,281,2001
oral
pig 		lowest published toxic dose: 93 mg/kg (1-16 week pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) AJVRAH 36,23,1975
oral
rat 		lowest published toxic dose: 945 mg/kg (36 week prior to copulation) Reproductive: Other effects on female

Endocrine: Estrogenic 		AECTCV 3,479,1975/1976
oral
rat 		lowest published toxic dose: 1,890 mg/kg (36 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) AECTCV 3,479,1975/1976
oral
rat 		lowest published toxic dose: 1,250 mg/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FCTXAV 13,507,1975
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg (14 day prior to copulation) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		AECTCV 44,72,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 10 mg/m3 Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		85CYAB 2,153,1959
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): >1 gm/kg N/R AECTCV 6,279,1977
intraperitoneal
rat 		lowest published toxic dose: 160 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina RCOCB8 9,85,1974
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >3 gm/kg N/R AECTCV 6,279,1977
oral
rat 		lethal dose (50 percent kill): 4,250 mg/kg Eye: Chromodacryorrhea

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 24,434,1973
oral
rat 		lowest published toxic dose: 2,500 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BECTA6 13,14,1975
oral
rat 		lowest published toxic dose: 5,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 13,14,1975
subcutaneous
guinea pig 		lowest published lethal dose: 345 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		PHRPA6 59,1085,1944
subcutaneous
rat 		lowest published toxic dose: 190 mg/kg Endocrine: Estrogenic JAFCAU 18,1108,1970
skin
rabbit 		lowest published lethal dose: 1,269 mg/kg N/R ARVPAX 14,139,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
domestic animal 		lowest published toxic dose: 5 mg/kg/20 day- intermittent Liver: Other changes JEPOEC 12,17,1993
intramuscular
rabbit 		lowest published toxic dose: 25 mg/kg/20 day- intermittent Liver: Other changes JEPOEC 12,17,1993
intraperitoneal
rat 		lowest published toxic dose: 175 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXAPA9 48,185,1979
intraperitoneal
rat 		lowest published toxic dose: 1,600 mg/kg/10 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count 		TXAPA9 28,189,1974
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/2 day- intermittent Related to Chronic Data: Changes in uterine weight EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/5 day- intermittent Related to Chronic Data: Changes in uterine weight EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 48 mg/kg/2 day- intermittent Endocrine: Evidence of thyroid hypofunction JTEHD6 51,503,1997
intraperitoneal
rat 		lowest published toxic dose: 72 mg/kg/3 day- intermittent Endocrine: Evidence of thyroid hypofunction JTEHD6 51,503,1997
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/5 day- intermittent Endocrine: Evidence of thyroid hypofunction JTEHD6 51,503,1997
intraperitoneal
rat 		lowest published toxic dose: 400 mg/kg/2 day- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Changes in uterine weight 		BECTA6 53,583,1994
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/5 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/2 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		EVHPAZ 102,568,1994
oral
monkey 		lowest published toxic dose: 75,600 µg/kg/27 week- continuous Gastrointestinal: Other changes

Blood: Changes in cell count (unspecified)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		LAINAW 40,373,1979
oral
mouse 		lowest published toxic dose: 75,600 µg/kg/18 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		EVHPAZ 39,79,1981
oral
mouse 		lowest published toxic dose: 842 mg/kg/6 week- continuous Immunological Including Allergic: Decrease in humoral immune response DCTODJ 2,111,1979
oral
mouse 		lowest published toxic dose: 825 mg/kg/66 day- intermittent Endocrine: Changes in thymus weight REPTED 15,281,2001
oral
mouse 		lowest published toxic dose: 1,650 mg/kg/66 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 15,281,2001
oral
quail 		lowest published toxic dose: 12,200 mg/kg/61 day- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Conditioned vitamin deficiency 		BECTA6 9,179,1973
oral
rat 		lowest published toxic dose: 1,890 mg/kg/36 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal AECTCV 10,171,1981
oral
rat 		lowest published toxic dose: 366 mg/kg/61 day- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Lipids including transport 		BECTA6 9,179,1973
oral
rat 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		BECTA6 13,456,1975
oral
rat 		lowest published toxic dose: 5,460 mg/kg/26 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		TXAPA9 32,461,1975
oral
rat 		lowest published toxic dose: 455 mg/kg/13 week- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 2,790 mg/kg/372 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 967.2 mg/kg/372 day- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 682.5 mg/kg/91 day- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BECTA6 13,14,1975
oral
rabbit 		lowest published toxic dose: 4,200 mg/kg/14 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		AJPAA4 70,363,1973
subcutaneous
domestic animal 		lowest published toxic dose: 20 mg/kg/20 day- intermittent Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPOEC 9,283,1989
subcutaneous
rabbit 		lowest published toxic dose: 25 mg/kg/20 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Other proteins 		JEPOEC 9,283,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 18,43,1978
TOXICOLOGY REVIEW
EVHPAZ 1,105,1972
TOXICOLOGY REVIEW
ARVPAX 14,139,1974
TOXICOLOGY REVIEW
RREVAH 44,1,1973
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
BISNAS 20,958,1970
TOXICOLOGY REVIEW
ENVRAL 5,249,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m3 (skin) DTLVS* 3,51,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (1 mg/m3), Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (1 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, Skin, 2A Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.01 mg/m3, KTV 0.3 mg/m3, Skin, Caecinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO POLYCHLORINATED BIPHENYLS-air Carcinogen;
10 hour time-weighted average 0.001 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1183;
Number of Industries 3;
Total Number of Facilities 58;
Number of Occupations 5;
Total Number of Employees Exposed 2,214;
Total Number of Female Employees Exposed 285


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027)
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Rodent dominant lethal
Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986
NIOSH Analytical Method, 1994: Polychlorobiphenyls, 5503; in serum, 8004
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85CYAB "Chemistry of Industrial Toxicology," 2nd ed., Elkins, H.B., New York, John Wiley & Sons, Inc., 1959
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BISNAS BioScience. (American Institute of Biological Sciences, 1401 Wilson Blvd., Arlington, VA 22209) V.14- 1964-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1952-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 11104-29-3
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