The Registry of Toxic Effects of Chemical Substances

Plumbane, tetraethyl -

RTECS #: TP4550000

CAS #: 78-00-2

UPDATE: May 2005 MW: 323.47 MF: C8H20Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Czteroetylek olowiu (Polish)
  2. Lead, tetraethyl -
  3. NCI - C54988
  4. NSC 22314
  5. Piombo tetra - etile (Italian)
  6. RCRA waste number P110
  1. TEL
  2. Tetraethyl lead
  3. Tetraethyl lead (ACGIH:OSHA)
  4. Tetraethylolovo (Czech)
  5. Tetraethylplumbane
  6. Tetraethylplumbium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform hamster embryo 12,500 µg/L AETODY 1,241,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg (14 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic BNEOBV 58,41,1990
intraperitoneal
rat 		lowest published toxic dose: 1,499 µg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		VHTODE 34,510,1992
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg (19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		VHTODE 34,510,1992
oral
mouse 		lowest published toxic dose: 11 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 13,629,1975
oral
rat 		lowest published toxic dose: 11 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 13,629,1975
oral
rat 		lowest published toxic dose: 7,500 µg/kg (12-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 21,265,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg/21 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		EXPEAM 24,580,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1,749 gm/m3/30 minute Olfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting 		SAIGBL 17,223,1975
inhalation
mouse 		lowest published lethal concentration: 650 mg/m3/7 hour N/R SAIGBL 15,3,1973
inhalation
rat 		lethal concentration (50 percent kill): 850 mg/m3/1 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis 		BJIMAG 18,277,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 15 mg/kg N/R MELAAD 54,486,1963
intravenous
rat 		lethal dose (50 percent kill): 14,400 µg/kg N/R MELAAD 54,486,1963
intravenous
rabbit 		lowest published lethal dose: 22 mg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 12,300 µg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression 		EXPEAM 28,923,1972
oral
rabbit 		lowest published lethal dose: 30 mg/kg N/R SAIGBL 15,3,1973
parenteral
rat 		lethal dose (50 percent kill): 15 mg/kg N/R AOHYA3 3,226,1961
subcutaneous
mouse 		lethal dose (50 percent kill): 13,020 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Convulsions or effect on seizure threshold 		FKIZA4 49,2779,1958
subcutaneous
rabbit 		lowest published lethal dose: 32 mg/kg N/R EQSSDX 1,1,1975
skin
dog 		lowest published lethal dose: 547 mg/kg N/R SAIGBL 15,3,1973
skin
guinea pig 		lowest published lethal dose: 995 mg/kg N/R SAIGBL 15,3,1973
skin
rabbit 		lowest published lethal dose: 830 mg/kg N/R SAIGBL 15,3,1973
unreported route
man 		lowest published lethal dose: 1,470 µg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,100 mg/m3/1 hour/5 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533656-1
intravenous
monkey 		lowest published toxic dose: 42 mg/kg/7 day- intermittent Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 2,187,1978
oral
rat 		lowest published toxic dose: 2,520 µg/kg/6 week- continuous Endocrine: Other changes JANSY* 8,287,1983
skin
dog 		lowest published toxic dose: 504 µL/kg/21 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FKIZA4 49,2779,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Pb)/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,230,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,230,1987
TOXICOLOGY REVIEW
JORCAI 76,265,1974
TOXICOLOGY REVIEW
JAMAAP 105,578,1935
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
85DHAX Pb,255,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg(Pb)/m3 (skin) DTLVS* 3,251,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.075 mg(Pb)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(Pb)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg(Pb)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.075 mg(Pb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.075 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.007 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 mg(Pb)/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.005 mg/m3, short term exposure limit 0.01 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.001 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.075 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg/m3, ktv 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.075 mg/m3), KZG- week 0.02 ppm, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.075 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.10 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAETHYLLEAD (as Pb)-air 10 hour time-weighted average 0.075 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71640;
Number of Industries 1;
Total Number of Facilities 85;
Number of Occupations 6;
Total Number of Employees Exposed 799
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71640;
Number of Industries 6;
Total Number of Facilities 729;
Number of Occupations 15;
Total Number of Employees Exposed 36,802;
Total Number of Female Employees Exposed 1,099


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as component of anti-knock mixes for gas and as intermediate in making fungicides
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl lead (as Pb), 2533
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JANSY* Journal of the autonomic nervous system (Amsterdam, Elsevier/North Holland Biomedical Press) V.1-81 1979-2000.
JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l, Switzerland) V.1- 1963-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as component of anti-knock mixes for gas and as intermediate in making fungicides

NIOSH PROFILE (ORGANIC LEAD), SRC, 10/77

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data

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