The Registry of Toxic Effects of Chemical Substances

Platinum

RTECS #: TP2160000

CAS #: 7440-06-4

UPDATE: November 2004 MW: 195.09 MF: Pt


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. C.I. 77795
  2. Liquid bright platinum
  3. Platin (German)
  1. Platinum Black
  2. Platinum sponge
  3. Platinum (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 23 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		NATWAY 42,75,1955
implant
rat 		lowest published toxic dose: 5,250 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		NATWAY 42,75,1955


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 17 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 57,38,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		GTPZAB 23(9),4,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.002 mg/m3 DTLVS* 3,213,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.001 mg/m3, short term exposure limit 0.002 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.002 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Pt)/m3, JAN1999
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PLATINUM (as Pt), metal-air 10 hour time-weighted average 1 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PLATINUM (as Pt), soluble salts-air 10 hour time-weighted average 0.002 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60125;
Number of Industries 3;
Total Number of Facilities 63;
Number of Occupations 4;
Total Number of Employees Exposed 680
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4385;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 28;
Total Number of Female Employees Exposed 7
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5987;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 1;
Total Number of Employees Exposed 23
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7504;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 428;
Total Number of Female Employees Exposed 407
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60125;
Number of Industries 16;
Total Number of Facilities 677;
Number of Occupations 26;
Total Number of Employees Exposed 22,935;
Total Number of Female Employees Exposed 3,498


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Metals in urine, 8310
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
OSHA ANALYTICAL METHOD #ID121


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (PLATINUM AND ITS COMPOUNDS), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Drug

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