The Registry of Toxic Effects of Chemical Substances

Piperazine, dihydrochloride

RTECS #: TL4025000

CAS #: 142-64-3

UPDATE: May 2004 MW: 159.08 MF: C4H10N2•2ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Diethylenediamine dihydrochloride
  2. Dihydro Pip Wormer
  3. Dihydrochloride salt of diethylenediamine
  4. Dowzene DHC
  1. Piperazine dihydrochloride (ACGIH)
  2. Piperazine hydrochloride
  3. Piperazine wormer premix


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,970 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation JJPAAZ 17,475,1967
oral
rat 		lethal dose (50 percent kill): 4,900 mg/kg N/R GUCHAZ 6,416,1973
subcutaneous
mouse 		lethal dose (50 percent kill): 2,030 mg/kg N/R ARZNAD 4,649,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) skin CFRGBR 29,1926.55,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PIPERAZINE-air 10 hour time-weighted average 5.0 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80559;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 5;
Total Number of Employees Exposed 1,284
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80559;
Number of Industries 1;
Total Number of Facilities 163;
Number of Occupations 12;
Total Number of Employees Exposed 5,730


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used in the manufacture of fibers, pharmaceuticals and insecticides

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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