The Registry of Toxic Effects of Chemical Substances

Picric acid

RTECS #: TJ7875000

CAS #: 88-89-1

UPDATE: November 2004 MW: 229.12 MF: C6H3N3O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acide picrique (French)
  2. Acido picrico (Italian)
  3. C.I. 10305
  4. Nitroxanthic acid
  5. Phenol trinitrate
  6. Phenol, 2,4,6 - trinitro -
  7. Carbazotic acid
  8. 2 - Hydroxy - 1,3,5 - trinitrobenzene
  9. Kyselina pikrova (Czech)
  10. Melinite
  1. Picric acid (ACGIH:OSHA)
  2. Picronitric acid
  3. Pikrinezuur (Dutch)
  4. Pikrinsaeure (German)
  5. Pikrynowy kwas (Polish)
  6. 2,4,6 - Trinitrofenol (Dutch)
  7. 2,4,6 - Trinitrofenolo (Italian)
  8. 1,3,5 - Trinitrophenol
  9. 2,4,6 - Trinitrophenol
  10. 2,4,6 - Trinitrophenyl (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 1,800 ppm (-enzymatic activation step) MUREAV 47,75,1978
mutation in microorganisms Salmonella typhimurium 5 µmol/plate (+/-enzymatic activation step) MUREAV 90,91,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		1,250 µmol/L MUREAV 90,91,1981
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		1,500 ppm ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 56,300 µg/kg Behavioral: Convulsions or effect on seizure threshold NYKZAU 56,450,1960
oral
cat 		lowest published lethal dose: 250 mg/kg N/R HBAMAK 4,1289,1935
oral
guinea pig 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
rat 		lethal dose (50 percent kill): 200 mg/kg Eye: Chromodacryorrhea

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JTEHD6 37,313,1992
oral
rabbit 		lowest published lethal dose: 120 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature increase 		XPHBAO 271,151,1941
subcutaneous
dog 		lowest published lethal dose: 60 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
pigeon 		lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
unreported route
dog 		lowest published lethal dose: 60 mg/kg Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		XPHBAO 271,151,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,212,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, KZG- week 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PICRIC ACID-air time-weighted average 0.1 mg/m3 (Sk);
short term exposure limit 0.3 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59450;
Number of Industries 17;
Total Number of Facilities 2,097;
Number of Occupations 14;
Total Number of Employees Exposed 21,627
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59450;
Number of Industries 20;
Total Number of Facilities 2,224;
Number of Occupations 26;
Total Number of Employees Exposed 37,003;
Total Number of Female Employees Exposed 21,627


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of dye intermediates and in manufacturing picrates
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used in synthesis of dye intermediates and in manufacturing picrates

NIOSH PROFILE (NITROPHENOLS), SRC, 4/81

RTECS Compound Description:
   Mutagen

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