The Registry of Toxic Effects of Chemical Substances

Picolinic acid, 4 - amino - 3,5,6 - trichloro -

RTECS #: TJ7525000

CAS #: 1918-02-1

UPDATE: November 2004 MW: 241.46 MF: C6H3Cl3N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Pyridinecarboxylic acid, 4 - amino - 3,5,6 - trichloro -
  2. 3,5,6 - Trichloro - 4 - aminopicolinic acid
  3. 4 - Amino - 3,5,6 - trichloro - 2 - picolinic acid
  4. 4 - Amino - 3,5,6 - trichloropicolinic acid
  5. 4 - Amino - 3,5,6 - trichlorpicolinsaeure (German)
  6. ATCP
  7. Amdon
  8. Amdon grazon
  1. Borolin
  2. Grazon
  3. K - Pin
  4. NCI - C00237
  5. Picloram
  6. Picloram (ACGIH:OSHA)
  7. Picloram, acid
  8. Tordon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms other microorganisms 200 µg/plate (-enzymatic activation step) MUREAV 57,277,1978
mutation in microorganisms Saccharomyes cerevisiae 100 mg/L (-enzymatic activation step) TGANAK 18,455,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTXAV 10,797,1972
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system FCTXAV 10,797,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 340 gm/kg/80 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors 		JTEHD6 7,207,1981
oral
rat 		lowest published toxic dose: 208 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors 		JTEHD6 7,207,1981
oral
rat 		toxic dose : 208 gm/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-23,1978
oral
rat 		toxic dose : 416 gm/kg/80 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Endocrine: Tumors 		NCITR* NCI-TR-23,1978
oral
rat 		toxic dose : 417 gm/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors 		JTEHD6 7,207,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
duck 		lethal dose (50 percent kill): >2 gm/kg N/R DOEAAH 35,25,1979
oral
rat 		lethal dose (50 percent kill): 4,012 mg/kg N/R FEREAC 64,420,1999
oral
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R GUCHAZ 6,414,1973
skin
rabbit 		lethal dose (50 percent kill): >4 gm/kg N/R WRPCA2 9,119,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		AECTCV 24,449,1993
oral
rat 		lowest published toxic dose: 7 gm/kg/2 week- continuous Liver: Changes in liver weight JTEHD6 20,367,1987
oral
rat 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		JTEHD6 20,367,1987
oral
rat 		lowest published toxic dose: 10,920 mg/kg/26 week- continuous Liver: Changes in liver weight JTEHD6 20,367,1987
oral
rat 		lowest published toxic dose: 73 gm/kg/1 year- continuous Liver: Changes in liver weight JTEHD6 20,367,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 53,481,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,481,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,481,1991
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,143,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83786;
Number of Industries 1;
Total Number of Facilities 12;
Number of Occupations 1;
Total Number of Employees Exposed 72
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83786;
Number of Industries 1;
Total Number of Facilities 45;
Number of Occupations 2;
Total Number of Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat NCITR* NCI-TR-23,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-23,1978


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

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