The Registry of Toxic Effects of Chemical Substances

3 - Picoline

RTECS #: TJ5000000

CAS #: 108-99-6

UPDATE: December 2000 MW: 93.14 MF: C6H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. beta - Picoline
  2. m - Picoline
  3. beta - Methylpyridine
  1. m - Methylpyridine
  2. 3 - Methylpyridine
  3. Pyridine, 3 - methyl - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL/24 hour severe NTIS** OTS0534823
skin
rabbit 		200 µL/24 hour severe NTIS** OTS0534823


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 11,820 mg/m3/5 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0534823
intraperitoneal
mouse 		lethal dose (50 percent kill): 596 mg/kg N/R JPETAB 88,82,1946
intraperitoneal
rat 		lethal dose (50 percent kill): 150 mg/kg Behavioral: Somnolence (general depressed activity) FAATDF 5,920,1985
intravenous
mouse 		lethal dose (50 percent kill): 298 mg/kg N/R JPETAB 88,82,1946
oral
wild bird 		lethal dose (50 percent kill): 1 gm/kg N/R AECTCV 12,355,1983
oral
quail 		lethal dose (50 percent kill): 1 gm/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 400 mg/kg N/R 85JCAE -,841,1986
skin
guinea pig 		lethal dose (50 percent kill): 1 gm/kg N/R 85JCAE -,841,1986
skin
rabbit 		lowest published lethal dose: 200 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Gastrointestinal: Other changes 		NTIS** OTS0534823


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2579;
Number of Industries 2;
Total Number of Facilities 34;
Number of Occupations 2;
Total Number of Employees Exposed 5,202;
Total Number of Female Employees Exposed 390


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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